A plasma glycoprotein that is found in both the free state and covalently bound to the heavy chains of certain protease inhibitors. It may participate in cell growth, oocyte cumulus expansion and stabilization.


A gene on chromosome 9q32-q33 that encodes alpha-1-microglobulin/bikunin precursor protein, which is expressed in liver and secreted in plasma. Alpha-1-microglobulin belongs to the superfamily of lipocalin transport proteins and plays a role in regulating inflammation; bikunin belongs to the superfamily of Kunitz-type protease inhibitors and plays a key role in many physiological and pathological processes, by inhibiting trypsin, plasmin and lysosomal granulocytic elastase, as well as calcium oxalate crystallisation.
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The paper is titled "The proteoglycan bikunin has a defined sequence.
Exposure of renal epithelial cells to CaOx crystals results in the increased synthesis of osteopontin, bikunin, heparan sulphate, monocyte chemoattractant protein (MCP)-l, and prostaglandin (PG) E2, which are known to participate in inflammatory processes and in extracellular matrix production.
Immunohistochemical demonstration of bikunin, a light chain of inter-[alpha]-trypsin inhibitor, in human brain tumors.
through which Signet will conduct research with immunoassays discovered by Bayer scientists that detect two markers of inflammation, uristatin (Uri) and bikunin (Bik), found in blood and urine.
Bikunin is the active subunit of protein/carbohydrate complexes that together comprise the inter-[alpha]inhibitor protein family, which plays a major role in extracellular matrix stability and integrity (Bost et al.
Finally, the use of recombinant bikunin as a xylose acceptor enabled an accurate and sensitive determination of XT-I activity, even in human serum (13,14).
Discovered by Bayer scientists, the immunoassays detect two markers of inflammation, uristatin (Uri) and bikunin (Bik), found in blood and urine.
Plasma bikunin as a favorable prognostic factor in ovarian cancer.
The first poster, "Effects of the Serine Protease Inhibitor, Bikunin (SPINT2), on Nasal Epithelium Potential Difference in Cynomolgus Monkeys: A Novel Treatment for CF," demonstrated that AER-002 could control how salt is regulated in the lung -- an important function in managing CF.
Unlike other members of the inter-[alpha]-trypsin inhibitor family (12, 13), ITIH4 is present in plasma as a single-chain protein because its COOH terminus lacks the consensus sequence (DPHFII) for bikunin assembly through the glycosaminoglycan bridges (2, 3, 12-14).
Under the terms of the agreement, in exchange for a minority equity stake in Aerovance, Bayer Pharmaceuticals Corporation has spun out the rights to two lead products to Aerovance: an IL4/13 receptor antagonist (AER-001) for severe asthma entering Phase II studies and Bikunin (AER-002), a recombinant therapeutic protein for cystic fibrosis and chronic obstructive pulmonary disease (COPD) on track for the filing of an investigational new drug (IND) application.