Also found in: Dictionary, Thesaurus, Wikipedia.
Related to biguanides: Sulfonylureas
biguanidesDrugs, such as METFORMIN and PHENFORMIN used to treat Type II DIABETES. They are part of the group of oral hypoglycaemic drugs. Biguanides act by reducing the efficiency of ION movement across cell membranes thus interfering with the production of glucose by the liver and reducing the energy yield from glucose used as fuel.
metforminbiguanide agent used to treat diabetes mellitus; in presence of insulin, it decreases hepatic gluconeogenesis and increases peripheral uptake of glucose (i.e. it decreases peripheral insulin resistance); it is used to treat type 2 diabetes in cases that retain some endogenous pancreatic function, obese diabetics, and those whose blood glucose levels are not adequately controlled by sulphonylureas alone; also used in conjunction with sulphonylureas or acarbose or injected insulin or a glitazone or repaglinide; also used to treat some type 1 diabetics where it is used as an adjunct to parenteral (administered) insulin; may be used to treat polycystic ovary disease (these patients typically show insulin resistance, even though not frankly diabetic)
n.pl orally administered agents used in the treatment of type 2 diabetes, which prevents the liver from breaking down glycogen into glucose and increases the sensitivity body tissues have to insulin. See metformin HCl.
a class of disinfectants, the most common one being chlorhexidine.