biguanides


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Related to biguanides: Sulfonylureas

biguanides

Drugs, such as METFORMIN and PHENFORMIN used to treat Type II DIABETES. They are part of the group of oral hypoglycaemic drugs. Biguanides act by reducing the efficiency of ION movement across cell membranes thus interfering with the production of glucose by the liver and reducing the energy yield from glucose used as fuel.

metformin

biguanide agent used to treat diabetes mellitus; in presence of insulin, it decreases hepatic gluconeogenesis and increases peripheral uptake of glucose (i.e. it decreases peripheral insulin resistance); it is used to treat type 2 diabetes in cases that retain some endogenous pancreatic function, obese diabetics, and those whose blood glucose levels are not adequately controlled by sulphonylureas alone; also used in conjunction with sulphonylureas or acarbose or injected insulin or a glitazone or repaglinide; also used to treat some type 1 diabetics where it is used as an adjunct to parenteral (administered) insulin; may be used to treat polycystic ovary disease (these patients typically show insulin resistance, even though not frankly diabetic)

biguanides (bīgwan´īdz),

n.pl orally administered agents used in the treatment of type 2 diabetes, which prevents the liver from breaking down glycogen into glucose and increases the sensitivity body tissues have to insulin. See metformin HCl.

biguanides

a class of disinfectants, the most common one being chlorhexidine.
References in periodicals archive ?
Biguanides have been shown to prevent progression in these patients to frank diabetes.
Until recently, treatment options were limited to primarily two classifications of drugs: biguanides and sulfonylureas.
Further analysis showed that almost 39% (n = 62 717) of the "combination therapy" prescriptions were for a sulfonylurea in combination with a biguanide plus one or more other antidiabetic medicine (including insulin, meglitinides, thiazolidinediones, alpha-glucosidase inhibitors, sulfonylureas and biguanides).
Description: propylene glycol (and) formic acid (and) iodopropynyl butylcarbamate (and) polyaminopropyl biguanides
1c] with basal insulin supplement, sulfonylurea, or biguanide therapy in maturity-onset diabetes: a multicenter study.
excessive doses of insulin or some diabetes medications, including sulfonylureas and meglitinides (Alpha-glucosidase inhibitors, biguanides, and thiazolidinediones alone should not cause hypoglycemia but can when used with other diabetes medicines.
Fast acting Insulins, Long acting Insulins, Intermediate and Fast acting Insulins, Intermediate acting Insulins, Biguanides, Glitazone and Biguanide combinations, Biguanide and Sulphonylurea combinations, Glinides, Sulphonylureas, Glitazones, DPP-IV Inhibitors, Glp-1 Agonists, Alpha-Glucosidase Inhibitors, DPP-IV Inhibitor and Biguanide combinations, Glitazone and Sulphonylurea combinations, SGLT Inhibitors, SGLT Inhibitor and Biguanide combinations, PTP1B Inhibitors and all other Oral Antidiabetic classes.
Also find individual revenue forecasts to 2025 for nine therapeutic submarkets at world level: -- Human insulins and analogues -- Dipeptidyl peptidase-4 inhibitors (DPP-4) -- Biguanides -- Glucagon-like peptide-1 receptor agonists (GLP-1) -- Sulfonylureas.
The drug belongs to a class of medicines known as biguanides, which have been used for decades to treat type 2 diabetes, which usually affects obese people and those over 40.
Drug classes discussed include biguanides (metformin), DPP4 inhibitors, GLP-1 agonists, PPAR, secretagogues, SGLT2, GPR-119, insulins and (briefly) amphetamines.
To calculate the market size, the Global Type 2 Diabetes Therapeutics Market 2015-2019 report considers revenue generated through the sales of drugs like DPP-4 inhibitors, Biguanides, Insulins, GLP-1 receptor agonists, Thiazolidenediones, Sulfonulureas, SGLT-2 inhibitors, a-Glucosidase inhibitors and others (amylinomimetics, bile acid sequestrants, and dopamine receptor agonists).