2) The cartilage tissue of the patients with osteoarthritis and rheumatoid arthritis include biglycan
fragments obtained due to breakdown of proteoglycans by ADAMTSs.
They also found significant increased mRNA expression of extracellular matrix proteins biglycan
and decorin and concluded that PRP appears to enhance the healing of meniscal defects.
The key protein Biglycan
restores the muscle-strengthening presence of a protein called utrophin, which is normally prevalent only in very young children.
Candidate polysaccharide or proteoglycan subunits include aggrecan, agrin, bamacan, heparan sulfate, chondroitin sulfate, keratan sulfate, versican, phosphocan, perlecan, hyaluronan, decorin, dermatan sulfate, biglycan
, fibromodulin, alginate, polylactate, polyglycolic acid, starch, dextran, agarose, chitan, chitosan, and heparin.
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
Two sequence-specific peptide antisera (LF-15 and LF-30) generated against synthetic peptides corresponding to amino acids 11-24 and 5-17 of the human core proteins of 2 small leucine-rich proteoglycans, biglycan
and decorin, were used to characterize territorial or interterritorial cartilage matrices.
Funding Supplements Tivorsan Pharmaceuticals' Commercialization Efforts of Biglycan
as Novel Disease-Modifying Therapeutic
Each transcriptional factor then regulates its target genes such as E-cadherin, MMPs, integrin and biglycan
leading to epithelial-mesenchymal transition (EMT), migration and invasion (Wu 2006).
Grant Funds Work of Tivorsan Pharmaceuticals' Team to Bring Recombinant Biglycan
to the Clinic for the Possible Treatment of Duchenne Muscular Dystrophy
An industry expert panel affiliated with Windhover selected Tivorsan's Biglycan
in the category of "Hot Space" therapeutic areas, inclusive of projects in Women's Health, Dermatology, Bone and Muscle Disease, Ophthalmology and other high value areas.
Food and Drug Administration (FDA) for a recombinant humanized form of biglycan
as a potential muscular dystrophy treatment.
Study published in PNAS shows recombinant human biglycan
reduces muscle damage and improves function in mouse model of DMD