macroprolactin

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macroprolactin

A large (±100-kD), noncleaved, physiologically inactive form of prolactin, which is bound to IgG and interferes with immunoassays.
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Maintained fertility in a patient with hyperprolactinemia due to big, big prolactin.
Characterization of big, big prolactin in patients with hyperprolactinaemia.
Hyperprolactinemia due to big big prolactin is differently detected by commercially available immunoassays.
Big prolactin (60 kDa) and macroprolactin (150 kDa), which are present in serum in varying quantities, can cause apparent hyperprolactinemia, but they have no clinical importance because they exhibit little biological activity.
The polyethylene glycol (PEG) precipitation test is widely used to detect pseudohyperprolactinemia caused by big prolactin and/or macroprolactin.
Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays.
Some forms of big big prolactin behave as complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma.
The most common form in healthy persons and in most patients with hyperprolactinemia is a monomeric prolactin (Mr 23 000), but higher molecular mass forms such as big prolactin (Mr 60 000) and big-big prolactin, or macroprolactin (Mr 150 000), sometimes predominate (1-4).
To facilitate more precise quantification of Mr 60 000 big prolactin, we chromatographed 4 sera over Sephacryl S-100 (40 x 1.
Maintained fertility in a patient with hyperprolactinaemia due to big, big prolactin.
Big big prolactin, or macroprolactin, a prolactin-IgG complex with a molecular mass of -150 kDa according to reports, accounts for a small but variable percentage of total prolactin (2, 3).
Big, big prolactin, or macroprolactin, has been described as the major immunoreactive prolactin species in the serum of several subjects before and during pregnancy (5, 9-11).