We report the case of a patient with CLL who developed biclonal gammopathy with rapid progression and resistance to treatment.
Compared to monoclonal gammopathies, reports of biclonal proteins are very few and the finding of biclonal gammopathy in CLL is very rare.
Since very few cases of CLL with biclonal gammopathy have been reported, it is difficult to draw any conclusions.
A surgical case of solitary plasmacytoma of rib origin with biclonal gammopathy
Chronic lymphocytic leukemia with associated lambda-light-chain and IgG lambda paraproteins simulating a biclonal gammopathy
is associated with similar disorders (5) The distribution between various clinical entities, the clinical features of the patients as well as the prognosis seem to be similar to those of monoclonal gammopathies (6).
Pseudotumoral lesions involving the mammary glands, the liver, or the spleen and, recently, glomerulonephritis and cases of monoclonal and biclonal gammopathy
have also been associated with B.