Juge-Morineau et al analysed the immunoglobulin heavy chain V-region (Ig HV) genes of three IgD, one IgM, and one biclonal
(IgG and IgM) multiple myeloma for the presence of somatic mutations based on molecular analysis of the Ig HV.
27) In case 3, the biclonal
paraprotein did not necessarily contravene the diagnosis of LPL because the isotype of the M-protein is not a defining feature of LPL.
gammopathy, defined as the simultaneous appearance of two different monoclonal protein components, is rare.
3], suspendidas las medicaciones relacionadas con trombocitopenia (Hidroclorotiazida, alfametildopa, Valsartan), solicitados marcadores de hemolisis negativos, serologias para hepatitis B, C, VEB, HIV, CMV negativas, TAC de torax y abdomen normal, electroforesis de proteinas sericas con pico biclonal
kappa y lambda, puncion de medula osea con reporte hipercelular.
A surgical case of solitary plasmacytoma of rib origin with biclonal
Chronic lymphocytic leukemia with associated lambda-light-chain and IgG lambda paraproteins simulating a biclonal
In rare conditions, electrophoresis produces more than one narrow peak simultaneously, suggesting the existence of more than one clonal antibody and establishing a biclonal
, triclonal or oligoclonal gammopathy (3).
Pseudotumoral lesions involving the mammary glands, the liver, or the spleen and, recently, glomerulonephritis and cases of monoclonal and biclonal
gammopathy have also been associated with B.
Taken in sum, however, the concept of monoclonal origin of most fibroids appears to be a valid one, recognizing that some could be biclonal
in origin (Ozisik et al.
Subsequent 24-hour urine showed 1,720 mg protein and urine protein electrophoresis revealed a biclonal
M spike of IgG and IgA, which was also found in the serum.
Tokla and Burnie, planted in the 1970s, contain some polyclonal or biclonal
For example, the use of high-resolution protein electrophoresis with immunofixation to confirm monoclonal and biclonal
paraprotein patterns has had a major impact on the practice of medicine at our hospital.