Cyclooxygenase-1 and bicistronic
cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction.
Interestingly, S2 is transcribed as a single message with tat and env (tricistronic message) or alternatively in a bicistronic
message with env alone (Fig.
In the current study, a bicistronic
expression based on the encephalomyocarditis virus internal ribosomal entry site (ECMV IRES) element was used for the development of Chinese hamster ovary (CHO)-stable cell pools expressing an anti-CD52 antibody.
A ZF [gamma]1-synuclein expression construct ([gamma]1-DsRed) composed of a T2A bicistronic
configuration, driven by the HuC neuronal promoter and expressing monomeric DsRed, was used as previously described (Prabhudesai et al.
Moreover, some reports have shown that presence of bicistronic
vectors is also helpful for efficiency of gene adjuvants (30).
Using state-of-the-art molecular cell biology including siRNA knockdown and reconstitution through bicistronic
retroviral mediated transfections, as well as genome editing we will generate stable cell lines expressing WT and functionally defined AP2 mutants.
There are two ways of heterologous co- expression of two genes: the bicistronic
(Li et al.
Enhancement of the immunogenicity of an infectious laryngotracheitis virus ADN vaccine by a bicistronic
plasmid encoding glycoprotein B and interleukin-18.
subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus.
Mutation of the signal peptide region of the bicistronic
gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization.
The human double sex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic
In a study of 12 patients with recurrent glioblastoma multiforme the therapeutic potential of combining HSVtk and IL-2 using a bicistronic
Moloney vector, was reported using retroviral VPC (25,31).