biallelic

biallelic

adjective Referring to 2 alleles.
References in periodicals archive ?
246) In cases with biallelic HNF1 b inactivation, expression of PKHD1 and uromodullin was turned off.
First, the elements of sequences between imprinted and control genes had distinguishing sequence characteristics, because the sequences of imprinted genes were more regular than biallelic genes.
We have ongoing Phase 2 clinical trials designed to build on our early studies in which we observed a significant correlation between the number of infused CD4+ T cells in which both copies of the CCR5 gene are modified, so-called biallelic modification, and reduction in viral load during a treatment interruption.
With separated loci, 3 genotype curves are expected for each biallelic locus.
To evaluate the minimal amount of template DNA in the MDA reaction necessary to retain biallelic representation, we compared results of the TagMan analyses (Table 1) and a panel of 254 SNPs analyzed by MS (Table 2) on QIAamp MiniKit-preps of 3 whole blood samples to those of MDA products from the dilution series of DBS DNA from the same samples.
0-log reduction in VL from peak achieved during the TI was observed in 3 of 6 subjects with the highest estimated circulating levels of cells with biallelic modification of their CCR5 gene.
Biallelic loss-of-function mutations in TCF2, the gene encoding hepatocyte nuclear factor 1a (HNF1a), has been identified in some hepatic adenomas, (11) and mutations resulting in Wnt/[beta]-catenin activation had also been identified in adenomas by another group.
110) Biallelic loss of INI1 leads to the development of aggressive lethal neoplasms, either lymphomas or rhabdoid tumors, in transgenic mice in which one INI1 allele had been deleted and the remaining allele inactivated.
These two traits under selection were genetically controlled by an infinite number of additive loci, each with infinitesimal effect (polygene effect), plus two identified biallelic QTL (A1, A2 and B1, B2).
Finally, FLT3/ITD+ specimens were divided by mutation level thresholds of 40% and 50%--the latter, a clinically relevant threshold associated with worse outcome and biallelic mutations in at least some cells.
Genetic distances within and across cattle breeds as indicated by biallelic AFLP markers.
This test revealed that the intestinal biopsy specimen from the case patient contained biallelic TCR gene rearrangements (one of which is shown in Fig.