TASE:BOLT), has received notice of allowance from the US Patent Office for its two key patent applications covering methods of use and compositions covering the use of betahistine
with olanzapine for the mitigation of the serious weight gain associated as a side effect of the antipsychotic drug.
He had also been treated with oral prednisone, betahistine
, diuretics, and liothyronine without benefit.
Founded by Biolight in 2005, Obecure is focused on the development of weight management drug therapies, based on clinical evidence showing that betahistine
(active drug in Histalean(TM)) is effective in reducing weight in obese women.
Treatment for subclinical cochlear hydrops parallels that of cochlear hydrops--mainly diuretics, diet modification, betahistine
, and corticosteroids as warranted.
Other Development and Commercialization Programs Once-Daily Betahistine
- The Company has initiated a pharmacokinetic study.
The active ingredient in Histalean(TM) is betahistine
, a known histaminergic effector, with an excellent safety profile, established in more than 130 million human exposures.
Accordingly, in addition to pursuing the global commercialization of its once-daily tramadol product, including preparations for product launch in Europe, Labopharm will continue to move forward aggressively with its development programs for a once-daily formulation of trazadone and a once-daily formulation of betahistine
, while slowing its development programs for a controlled-release formulation of gabapentin and a once-daily formulation of oxybutynin.
For many years, the mainstay of therapy for symptoms of classic unilateral Meniere s disease included various medical regimens such as low-salt diets, diuretics, carbonic anhydrase inhibitors, betahistine
and other vasodilators, calcium channel blockers, and vitamin supplements.
is a histamine-like drug, but unlike histamine it is centrally acting and only has an H1 receptor agonist and partial H3 receptor antagonist activity with no affinity to the H2 histamine receptor; thus explaining its relative safety in more than 130 million human exposures to-date.
The influence of betahistine
on the vestibular evoked potentials in patients with peripheral vestibular disorders.
Microser(TM) has a leadership position in Italy, holding 60% of the total 16 million Euros Italian betahistine
He was taking betahistine
, triamterene/hydrochlorothiazide, chlordiazepoxide, and lipoflavinoid.