beta-oxidation


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Related to beta-oxidation: acetyl-coA, deamination

beta-ox·i·da·tion

, β-oxidation
1. oxidation of the β-carbon (carbon 3) of a fatty acid, forming the β-keto (β-oxo) acid analogue; of importance in fatty acid catabolism;
2. the entire pathway for the catabolism of saturated fatty acids containing an even number of carbon atoms; beta-oxidation (1) is a part of this pathway; acetyl-CoA is a major product of this pathway.

beta-oxidation

(bā′tə-ŏk′sĭ-dā′shən, bē′-)
n.
The oxidative degradation of saturated fatty acids, occurring in a repeating cycle of steps in which a two-carbon unit is removed from the molecule during each cycle.

beta-oxidation

a catabolic process in which fatty acids are used by the body as a source of energy. The fatty acid molecules are converted through a series of intermediates into acetylcoenzyme A molecules, which then enter the tricarboxylic acid (TCA) cycle along with metabolites of carbohydrates and proteins.

beta-oxidation

The oxidative breakdown of fatty acids in the form of acyl-coA into acetyl-coA, by repeated oxidation at the beta-carbon atom, allowing them to participate in the citric acid cycle.
References in periodicals archive ?
Down-regulation of tetradecanoylcarnitine by EAS indicated the EAS treatment could recover the dysfunction of VLACD in MPTP-induced PD mice, the therapeutic effects of EAS may base on the regulation of the dysfunction of VLACD in mitochondrial beta-oxidation of long chain saturated fatty acids and fatty acid metabolism.
As a result of this decline in mitochondrial activity less fatty acids can be removed within adipocytes by uncoupled mitochondrial beta-oxidation and by re-esterification, as mitochondrial activity provides substrates for glyceroneogenesis.
Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.
Once inside the mitochondria, L-carnitine releases these fatty acids and they are broken down by beta-oxidation to produce ATP or energy.
Caffeic acid and chlorogenic acid significantly inhibited fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase activities, while they increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver compared to the high-fat group.
This reduction in fatty acid oxidation was accompanied by a significant decrease in the activity of the long-chain isoform of the last enzyme involved in fatty acid beta-oxidation, 3-ketoacyl coenzyme A (CoA) thiolase activity (IC(50) of 75 nmol/L).