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beta-oxidation

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beta-oxidation,
a catabolic process in which fatty acids are used by the body as a source of energy. The fatty acid molecules are converted through a series of intermediates into acetylcoenzyme A molecules, which then enter the tricarboxylic acid (TCA) cycle along with metabolites of carbohydrates and proteins.


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Deficiency of CPT II is the most common autosomal recessive disorder of mitochondrial beta-oxidation of long chain fatty acids.
Polyunsaturated Fatty Acids of Marine Origin Upregulate Mitochondrial Biogenesis and Induce Beta-Oxidation in White Fat," Diabetologia 48, 2365-2375 (2005).
Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.
 
 
 
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