restore or potentiate the activity of beta-lactam antibiotics.
In our search for beta-lactamase inhibitors
from natural resources, we found that the methanol extract of the roots of Fissistigma cavaleriei showed an inhibitory effect on beta-lactamase.
The future development of novel beta-lactams resistant to hydrolysis by these versatile enzymes and the discovery of highly potent "second generation" beta-lactamase inhibitors
are eagerly awaited.
They ordered beta-lactamase inhibitors
second most commonly, in about 30% of prescriptions.
Should a similar resistance phenotype disseminate, it might have strategic implications for the development of new beta-lactamase inhibitors
and for selection of beta-lactam compounds to associate wth inhibitors.
for the development and commercialization of small molecule beta-lactamase inhibitors
to overcome antibiotic resistance.
are agents that inhibit bacterial enzymes that destroy beta-lactam antibiotics and result in resistance.
Evaluation of beta-lactamase inhibitors
in disk tests for detection of plasmid-mediated AmpC _beta-lactamases in well-characterized clinical strains of Klebsiella spp.
AmpC beta-lactamases are resistant to all marketed beta-lactamase inhibitors
pneumoniae from Singapore, were resistant to all carbapenems, penicillins and cephalosporins, and these resistance cannot be overcome with any beta-lactamase inhibitors
Evaluation of PPI-0903 (TAK-599), a Novel Cephalosporin: Bacterial Activity, Effects of Modifying Testing Parameters and Optimization of Disk Diffusion Tests, Saturday, October 30, 1:30 PM, Novel beta- Lactams: beta-Lactamase Inhibitors
, Cephalosporins, Carbapenems and Penicillins, H.
Entirely new beta-lactamase inhibitors
that kill many of the infectious bacteria that are currently resistant to most of the modern antibiotics.