beta-lactamase


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to beta-lactamase: beta-lactamase inhibitors, beta-lactamase resistant penicillin

β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
Detection of extended spectrum beta-lactamases in members of the family Enterobacteriaceae: comparison of the double-disk and three-dimensional tests.
ZOSYN is contraindicated in patients with a history of these reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
In vitro activity of N-formimidodoyl thienamycin (MK 0787) compared with other beta-lactamase stable cephalosporins against beta-lactamase producing Staphylococcus aureus.
Patent #6,884,791 on April 26, 2005 entitled "Novel Inhibitors of Beta-Lactamase," which provides protection for compounds and methods of treating bacterial infections.
Family physicians and specialists wrote predominantly for beta-lactamase inhibitors, in about 40% of prescriptions for upper respiratory tract infections.
Next, the researchers bred ordinary fowl with those hens and roosters that expressed beta-lactamase in their sperm or ovules.
One such mechanism of resistance found in gram-negatives is Extended Spectrum Beta-Lactamase (ESBL) in which enzymes produced by bacteria attack and cleave the beta-lactam ring in antibiotics, thus rendering them ineffective.
Roche, Meiji Seika Pharma (Meiji) and Fedora announced today that they have entered into a license agreement for the development and commercialization of OP0595, a beta-lactamase inhibitor in phase I clinical development.
Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR.
Detection of extended spectrum beta-lactamase from clinical isolates in Davangere.

Full browser ?