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beta-glucuronidase

   Also found in: Encyclopedia, Wikipedia 0.04 sec.
β-glucuronidase /β-glu·cu·ron·i·dase/ (gloo″ku-ron´ĭ-dās) an enzyme that attacks terminal glycosidic linkages in natural and synthetic glucuronides and that has been implicated in estrogen metabolism and cell division; it occurs in the spleen, liver, and endocrine glands; deficiency results in Sly's syndrome.
beta-glucuronidase
n.
An enzyme the catalyzes the hydrolysis of various proteoglycans.

β-glucuronidase
an enzyme which attacks glycosidic linkages in natural and synthetic glucuronides; occurs in the spleen, liver and endocrine glands.

g. deficiency
is the basis for mucopolysaccharidosis type VII in humans, dogs and inbred mice.


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Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells.
After 3 weeks, the transplanted cells had penetrated diverse regions of the brain and produced beta-glucuronidase, the enzyme that victims of Sly syndrome cannot make.
If beta-glucuronidase levels go unchecked, they may not only reverse glucuronidation but allow toxins to remain in the body to potentially cause cell damage.
 
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