beta-glucuronidase


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β-glucuronidase

/β-glu·cu·ron·i·dase/ (gloo″ku-ron´ĭ-dās) an enzyme that attacks terminal glycosidic linkages in natural and synthetic glucuronides and that has been implicated in estrogen metabolism and cell division; it occurs in the spleen, liver, and endocrine glands; deficiency results in Sly's syndrome.

beta-glucuronidase

, β-glucuronidase (bāt′ă-gloo″kū-ron′ĭ-dās″)
An enzyme found in lysosomes. It is involved in the breakdown of glycosaminoglycan.

β-glucuronidase

an enzyme which attacks glycosidic linkages in natural and synthetic glucuronides; occurs in the spleen, liver and endocrine glands.

g. deficiency
is the basis for mucopolysaccharidosis type VII in humans, dogs and inbred mice.
References in periodicals archive ?
Enzyme potentiated hyposensitization III: Control by sugars and diols of the immunological effect of beta-glucuronidase in mice and patients with hay fever.
Opiate Hydrolysis by a Novel Recombinant Beta-Glucuronidase for Urinalysis.
Alex and Gallant (2008) cite studies, which suggest that breastmilk is rich in beta-glucuronidase (increases uptake of unconjugated bilirubin).
Vials containing beta-glucuronidase and antigen mixes are manufactured in England by McEwen Laboratories, Ltd.
Three of their products, avidin, beta-glucuronidase and aprotinin (a protease inhibitor commonly used by surgeons), have been produced in sufficient quantities to be sold through a commercial chemical supplier, the St.
On-line deconjugation of chloramphenicol-[beta]-D-glucuronide on an immobilized beta-glucuronidase column.
After 3 weeks, the transplanted cells had penetrated diverse regions of the brain and produced beta-glucuronidase, the enzyme that victims of Sly syndrome cannot make.
If beta-glucuronidase levels go unchecked, they may not only reverse glucuronidation but allow toxins to remain in the body to potentially cause cell damage.
Ultragenyx) announced the presentation of preliminary data from the Phase 1/2 study of recombinant human beta-glucuronidase (rhGUS, UX003), an investigational therapy for the treatment of mucopolysaccharidosis (MPS 7, sly syndrome).
The very low dose allergen is combined with the enzyme beta-glucuronidase.
The role of beta-glucuronidase in drug disposition and drug targeting in humans.
D-Glucarate functions by inhibiting the dangerous beta-glucuronidase enzyme, thus protecting the critical "glucuronidation" detoxification mechanism.