HBB

(redirected from beta-globin)

HBB

A gene on chromosome 11p15.5 that encodes beta haemoglobin, which transports O2 in the circulation.

Molecular pathology
HBB mutations cause sickle cell anaemia, Heinz body anaemia, and various forms of beta thalassaemia.
References in periodicals archive ?
Both diseases manifest after birth, when patients switch from producing functional fetal gamma-globin to a mutant form of adult beta-globin, which causes their condition.
In his landmark 1978 study, Kan found that DNA-digesting enzymes cut two variants of the beta-globin gene differently because of a single nucleotide change.
Kan's laboratory in the United States and had created a new method for the identification of mutations in the beta-globin gene with usage for prenatal diagnosis (1).
The HBB gene provides instructions for making a protein called beta-globin.
5) is responsible for determining the condition of the beta-globin polypeptide (Segal et al.
Chapters introduce each type, then other chapters describe such specifics as genotyping mutation in the beta-globin gene with DNA microarrays, peptide microarrays for serum antibody diagnostics, and detecting entero-pathogenic Escherichia coli using microchip capillary electrophoresis.
Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia.
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences.
The Company's LentiGlobin(TM) hemoglobin gene therapy utilizes a modified human lentivirus to deliver a corrective version of the beta-globin gene to the chromosomes of blood stem cells.
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila.
Beta-globin primers had a final concentration of 0.
Targeting of antisense DNA: comparison of activity of anti-rabbit beta-globin oligodeoxyribonucleoside phosphorothioates with computer predictions of mRNA folding.