References in periodicals archive ?
Amplification refractory mutation system-polymerase chain reaction was found to be a very sensitive method to find the known point mutations present in beta-globin gene.
Understanding the control of the developmentally regulated switch of gene expression within the beta-globin locus is a mainly used in today research.
SCD is an inherited disease caused by a mutation in the beta-globin gene that results in sickle-shaped red blood cells.
The most common inherited diseases in humans result from mutations in the beta-globin gene com-plex and the alpha-globin gene complex.
Four protein subunits collectively form a haemoglobin molecule, two beta-globin chains and two alpha globin chains.
Hb E is formed by a substitution of glutamic acid by lysine at codon 26 of the [beta]-globin gene as a result of a splice site mutation on exon 1 of the beta-globin gene.
Identification and molecular characterization of four new large deletions in the beta-globin gene cluster.
In his landmark 1978 study, Kan found that DNA-digesting enzymes cut two variants of the beta-globin gene differently because of a single nucleotide change.
Cleaves the normal beta-globin gene into fragments two.
Kan's laboratory in the United States and had created a new method for the identification of mutations in the beta-globin gene with usage for prenatal diagnosis (1).
It is caused by an inherited mutation in the beta-globin gene that makes red blood cells change from their normal shape, which is round and pliable (like a plastic bag filled with corn oil), into a rigid sickle-shaped cell (like a corn flake).
LentiGlobin introduces a fully functional human beta-globin gene into the patient's own hematopoietic stem cells.