beta-galactosidase


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β-ga·lac·to·sid·ase

(gă-lak'tō-sīd'ās),
An enzyme that hydrolyzes the β-galactoside linkage in lactose-producing glucose and galactose; also hydrolyzes the chromogenic substrate IPTG (isopropylthiogalactoside) and thus is used as an indicator of fused genes and gene expression.

beta-galactosidase

See lactase.

GLB1

A gene on chromosome 3p21.33 that encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyses the terminal beta-galactose from gangliosides and other glycoconjugates.

Molecular biology
GLB1 mutations cause GM1-gangliosidosis and mucopolysaccharidosis IV (Morquio B syndrome).

β-galactosidase


β-galactosidase

a lysosome hydrolase.
References in periodicals archive ?
DiscoveRx pioneered the use of beta-galactosidase enzyme fragment complementation in biochemical and cell based assays for discovery research and holds extensive intellectual property in this area.
Like other PathHunter technologies, the Mitotic Index assays are engineered biosensor cell lines with separate nuclear and cytoplasmic fragments of Beta-galactosidase.
Labels specifically claimed include green fluorescent protein (GFP), beta-galactosidase, and luciferase.
The first grant is aimed at accelerating research into providing high throughput, homogeneous methods for G-Protein coupled receptor binding assays (GPCR) using the DiscoveRx core technology of complementation of inactive fragments of beta-galactosidase as a signal amplification method.
Flow cytometry was utilized to rapidly assess the cell uptake efficiency and toxicity of fluorescence-labeled siRNA targeting the inhibition of beta-galactosidase expression.
United States Navy -- entered into two Cooperative Research and Development Agreements (CRADAs) to evaluate the effectiveness of electroporation-mediated delivery of Luciferase, Beta-galactosidase (B-gal) and human secreted embryonic alkaline phosphatase (SEAP) marker genes.
For the purpose of evaluating the effectiveness of gene delivery, the first agreement will investigate the electroporation-mediated delivery of Luciferase, Beta-galactosidase (B-gal) and human secreted embryonic alkaline phosphatase (SEAP) marker genes to porcine muscle.
Our patent portfolio in genomics includes GFP (green fluorescent protein) technology, the beta-lactamase platform and certain applications of the beta-galactosidase reporter gene.
The disorder is "caused by mutations in the GLB1 gene, which encodes an enzyme called beta-galactosidase necessary for recycling of a molecule (GM1-ganglioside) in neurons.
Regulation expression by readthrough translation from a plasmid-encoded beta-galactosidase.
Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.