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beta-amyloid

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beta-amyloid
A4, β—amyloid Neurology A 4 kD polypeptide encoded on chromosome 21 arising from altered processing of amyloid precursor protein, an integral membrane glycoprotein secreted as a truncated carboxyl-terminal molecule; BA forms plaques in the brains of Pts with Alzheimer's disease–AD, Down syndrome, infectious encephalopathy, cerebral amyloid angiopathy; BA is found in skin, intestine, adrenal gland. See Alzheimer's disease, Amyloid, Presenilin. Cf Alpha2-macroglobulin.


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The study showed that applying Reelin directly to brain slices from mice prevents excess beta-amyloid from completely silencing nerves.
Intellect's immunotherapy approach for Alzheimer's disease involves making an antibody molecule available to bind to the beta-amyloid toxin, thus promoting its clearance away from sites of damage in the brain.
Beta-amyloid peptide is considered to be responsible for the formation of senile plaques that accumulate in the brains of patients with Alzheimer's disease.
 
 
 
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