ADRB3

(redirected from beta-3 adrenergic receptor)

ADRB3

A gene on chromosome 8p12 that encodes beta-1-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB3 is located primarily in adipose tissue and is involved in regulating lipolysis and thermogenesis.
References in periodicals archive ?
Developed by scientists at NTU, the new type of skin patch contains hundreds of micro-needles, each of them thinner than a human hair, which are loaded with the drug beta-3 adrenergic receptor agonist or another drug called triiodothyronine, containing thyroid hormone T3.
It contains a beta-3 adrenergic receptor agonist combined with hyaluronic acid, a substance naturally found in the human body and commonly used in products like skin moisturisers.
The first agent is mirabegron (Myrbetriq), which is the first FDA-approved beta-3 adrenergic receptor agonist.
Dow explains this is because they were developed before the human beta-3 adrenergic receptor had been identified.
The key classes of mechanism of action include acetylcholine antagonists/blockers, muscarinic receptor antagonists, beta-3 adrenoceptor antagonists, calcium influx inhibitors and intracellular calcium modulators, nonpeptide d-receptor agonists, neuronal serotonin and norepinephrine reuptake inhibitors, vanilloid receptor agonists, beta-3 adrenergic receptor agonists, noradrenaline reuptake inhibitors and NK1 receptor antagonists.
As outlined in this review, stepwise medical treatment for OAB is prudent and aimed at either competitively antagonizing the binding of acetylcholine to the muscarinic receptors (antimuscarinics), agonizing or stimulating the beta-3 adrenergic receptors (mirabegron), or blocking the release of acetylcholine at the bladder neuromuscular junction (botulinum toxin).
Other drugs may act on other kinds of receptors involved in weight gain, such as the beta-3 adrenergic receptors in fat tissue.