ADRB3

(redirected from beta-3 adrenergic receptor)

ADRB3

A gene on chromosome 8p12 that encodes beta-1-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB3 is located primarily in adipose tissue and is involved in regulating lipolysis and thermogenesis.
References in periodicals archive ?
Dow explains this is because they were developed before the human beta-3 adrenergic receptor had been identified.
The key classes of mechanism of action include acetylcholine antagonists/blockers, muscarinic receptor antagonists, beta-3 adrenoceptor antagonists, calcium influx inhibitors and intracellular calcium modulators, nonpeptide d-receptor agonists, neuronal serotonin and norepinephrine reuptake inhibitors, vanilloid receptor agonists, beta-3 adrenergic receptor agonists, noradrenaline reuptake inhibitors and NK1 receptor antagonists.
AMEX: ONC) announced today that Oncor and its majority-owned subsidiary, OncorPharm, have acquired an exclusive, world-wide license to a highly prevalent mutation of the human beta-3 adrenergic receptor (beta-3 AR), believed to play a significant long-term role in human obesity.
Other drugs may act on other kinds of receptors involved in weight gain, such as the beta-3 adrenergic receptors in fat tissue.