ADRB2

(redirected from beta-2 adrenergic receptor)

ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Beta-2 adrenergic receptor genetic polymor-phisms and asthma.
Genetic polymorphisms of the beta-2 adrenergic receptor in Israelis with severe asthma compared to non-asthmatic Israelis.
Flucatisone is a corticosteroid and salmeterol is a selective long-acting beta-2 adrenergic receptor agonist.
8 Association between Beta-1 and Beta-2 Adrenergic Receptor Polymorphism and Beta-blocker Therapy in Korean Heart Failure
New Findings Published in Molecular Cancer Therapeutics Demonstrate Novel and Selective Synergy for Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Combination with Standard of Care Drugs
CombinatoRx, Incorporated (NASDAQ: CRXX) today announced that preclinical data from its Adenosine A2A receptor (A2A) and Beta-2 Adrenergic Receptor (b2AR) Agonist oncology programs demonstrated synergistic anti-cancer activity when combined with standard-of-care therapies in multiple myeloma and other B-cell malignancies.
Preclinical Data on A2A and Beta-2 Adrenergic Receptor Agonist Programs in B-Cell Malignancies To Be Presented
Data presented during the conference included a review of the Company's adenosine A2A and beta-2 adrenergic receptor agonism programs; novel, selective and synergistic multiple myeloma targets that have demonstrated synergy with several drug classes and broad activity in multiple myeloma and other B-cell malignancy tumor cell lines.
Abstract #384, Monday, December 8, 2008: 12:15 PM, "Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel, Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening", Rickles, et al.
Stimulation of the former increases maternal heart rate and stroke volume, whereas stimulation of the beta-2 adrenergic receptors causes the relaxation of smooth muscle, including the muscles of the myometrium, blood vessels, and bronchial tree.
MN-221 is designed to help relax uterine smooth muscle via the selective stimulation of beta-2 adrenergic receptors.