Zhao (now Clinical Professor at Hackensack Medical University) further demonstrated the capacity of specific stem cells to differentiate into insulin secreting beta cells
The sequence of events for beta cell
dysfunction appears to be: (19)
The work, funded by the Health Research Board and the Mater Foundation, also showed that even in type 1 diabetics, the body continues to try and produce beta cells
The study is designed to evaluate whether a single course of otelixizumab, administered not more than 90 days after the initial diagnosis of autoimmune type 1 diabetes, will preserve beta cell
function as measured by c-peptide, a surrogate measure of beta cell
Liver cells were induced to become beta cells
that produce insulin and three other hormones.
At present, scientists do not know exactly what causes the body's immune system to attack the beta cells
, but they believe that both genetic factors and viruses are involved.
The pipeline analysis includes activities to preserve beta cell
mass and function by active and passive immunotherapy, by SIRT and gastrin based directions as well as anti-inflammatory approaches.
The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell
fate between survival or death remain to be clarified.
Research program will investigate an exciting new hypothesis about lost beta cell
function in type 1 diabetes that may change our basic understanding of the disease and lead to novel prevention and restoration therapies--
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell
In DEFEND, preserving beta cell
function subsequent to the administration of otelixizumab is the primary outcome that is being evaluated.
Team leader Dr Terry Strom said: "It would appear by altering the inflammatory state that surrounds this disease, you create an environment that enables expansion of the beta cell