beta cell


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beta cell

n.
1. Any of the insulin-producing cells of the islets of Langerhans in the pancreas.
2. Any of the basophilic chromophil cells located in the anterior lobe of the pituitary gland.

beta cell

A pancreatic endocrine cell that comprises up to 80% of the cells in the islets of Langerhans, which produces and releases insulin. Beta cells are destroyed or dysfunctional in type-1 diabetes, function suboptimally in type-2 diabetes and become neoplastic in insulinomas. Beta cells were once distinguished solely on the basis of differential staining from other cells designated A, C and D

beta cell

1. Any of the insulin-secreting cells of the pancreas that constitute the bulk of the islets of Langerhans. Synonym: B cell
2. A basophil cell of the adenohypophysis (anterior pituitary gland).
See also: cell
References in periodicals archive ?
Zhao (now Clinical Professor at Hackensack Medical University) further demonstrated the capacity of specific stem cells to differentiate into insulin secreting beta cells.
The sequence of events for beta cell dysfunction appears to be: (19)
The work, funded by the Health Research Board and the Mater Foundation, also showed that even in type 1 diabetics, the body continues to try and produce beta cells.
The study is designed to evaluate whether a single course of otelixizumab, administered not more than 90 days after the initial diagnosis of autoimmune type 1 diabetes, will preserve beta cell function as measured by c-peptide, a surrogate measure of beta cell function.
Liver cells were induced to become beta cells that produce insulin and three other hormones.
At present, scientists do not know exactly what causes the body's immune system to attack the beta cells, but they believe that both genetic factors and viruses are involved.
The pipeline analysis includes activities to preserve beta cell mass and function by active and passive immunotherapy, by SIRT and gastrin based directions as well as anti-inflammatory approaches.
The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell fate between survival or death remain to be clarified.
Research program will investigate an exciting new hypothesis about lost beta cell function in type 1 diabetes that may change our basic understanding of the disease and lead to novel prevention and restoration therapies--
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression.
In DEFEND, preserving beta cell function subsequent to the administration of otelixizumab is the primary outcome that is being evaluated.
Team leader Dr Terry Strom said: "It would appear by altering the inflammatory state that surrounds this disease, you create an environment that enables expansion of the beta cell mass.