benzodiazepine receptor


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benzodiazepine receptor

Any of a number of different receptors for benzodiazepine identified in the brain. BZ-1 receptors may affect neural pathways involved in normal sleep patterns, while BZ-2 receptors are involved in memory and motor functions.
References in periodicals archive ?
Central benzodiazepine receptor (BDZ-R) agonists have been known to induce multiple effects including anxiolytic, myorelaxant, anticovulsant, hypnotic and amnestic effects (44-46).
We know that the Z-drugs (zolpidem, zaleplon, and eszopiclone), some of the most widely used pharmacologies for insomnia, are benzodiazepine receptor agonists.
A] receptor antagonist, and flumazenil, a benzodiazepine receptor antagonist, were administered after oral administration and inhalation of KSS, respectively, the prolongation of pentobarbital-induced sleeping was significantly reduced.
Clinicians likely use benzodiazepine receptor agonists more than any other agent for insomnia.
Although the new hypnotics are riot in the benzodiazepine class, they interact with the benzodiazepine receptor.
The selective benzodiazepine receptor agonists (BZRAs), zopiclone and zolpidem, are chemically similar to the benzodiazepines and were developed as hypnotic agents with a shorter half-life to avoid a hangover effect.
Peripheral benzodiazepine receptor modulation by protoporphyrins can regulate cell death, cell proliferation, immunity and neural functions.
Flumazenil normally acts as a benzodiazepine receptor antagonist but has the properties of benzodiazepine agonist at receptors containing the a4 subunit (Wafford et al.
The issued patent identifies peripheral-type benzodiazepine receptor associated proteins, such as PAP7, and its ability to interact with and regulate the function of the peripheral-type benzodiazepine receptor, a key mitochondrial protein involved in steroid biosynthesis, cell proliferation, cancer progression, and Alzheimer's disease pathology.
New benzodiazepine receptor agonists for chronic insomnia--zaleplon, zolpidem, and eszopiclone--have shown fewer adverse effects compared with other medications, but additional studies are needed to assess these drugs' long-term effectiveness, concluded members of an independent panel convened by the National Institutes of Health in Bethesda, Md.
Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells," Anticaneer Research, September-October 2000.
9) For example, a dysregulated benzodiazepine receptor function has been described in GAD.