Any of a number of different receptors for benzodiazepine identified in the brain. BZ-1 receptors may affect neural pathways involved in normal sleep patterns, while BZ-2 receptors are involved in memory and motor functions.
A] receptor antagonist, and flumazenil, a benzodiazepine receptor antagonist, were administered after oral administration and inhalation of KSS, respectively, the prolongation of pentobarbital-induced sleeping was significantly reduced.
The selective benzodiazepine receptor agonists (BZRAs), zopiclone and zolpidem, are chemically similar to the benzodiazepines and were developed as hypnotic agents with a shorter half-life to avoid a hangover effect.
The issued patent identifies peripheral-type benzodiazepine receptor associated proteins, such as PAP7, and its ability to interact with and regulate the function of the peripheral-type benzodiazepine receptor, a key mitochondrial protein involved in steroid biosynthesis, cell proliferation, cancer progression, and Alzheimer's disease pathology.
New benzodiazepine receptor agonists for chronic insomnia--zaleplon, zolpidem, and eszopiclone--have shown fewer adverse effects compared with other medications, but additional studies are needed to assess these drugs' long-term effectiveness, concluded members of an independent panel convened by the National Institutes of Health in Bethesda, Md.