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benzodiazepine derivative

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benzodiazepine derivative
[ben′zōdī·az′əpin]
one of a group of psychotropic agents, including the tranquilizers chlordiazepoxide, diazepam, oxazepam, lorazepam, and chlorazepate, prescribed to alleviate anxiety, and the hypnotics flurazepam and triazolam, prescribed in the treatment of insomnia. Tolerance and physical dependence occur with prolonged high dosage. Withdrawal symptoms, including seizures, may follow abrupt discontinuation. Adverse reactions to the benzodiazepines include drowsiness, ataxia, and a paradoxic increase in aggression and hostility. These reactions are not common with the usual recommended dosage.


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Diazepam, first marketed as Vali-um is a benzodiazepine derivative drug, used as a highly effective tranquilliser and sedative, It is commonly used for treating anxiety, stress, tension insomnia, seizures, alcohol withdrawal, muscle spasms tension and anxiety and in some surgical procedures to induce amnesia.
Since the benzodiazepine derivative flunitrazepam (eg, in Rohypnol) has been used as a tool to incapacitate potential victims of, for example, robbery or rape, the pharmaceutical company Hoffmann La Roche mixes the Rohypnol tablets with the coloring agent indigo carmine to prevent its hidden admixture in beverages.
 
 
 
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