Nishiyama reports that midazolam, which is itself a water soluble benzodiazepine derivative
by virtue of being a benzodiazepine-GABAA receptor complex agonist, exhibits synergistic analgesia for thermally-induced acute nociception as well as persistent inflammatory nociceptive activation both with N-Methyl-DAspartica Acid (NMDA) and 2-amino-3-(5- methyl-3-oxo-12-oxazol-4-yl) Propanoic Acid (AMPA) receptor antagonists.
Adjunctive therapy with the benzodiazepine derivative
clobazam significantly reduced the occurrence of drop seizures in the largest clinical trial to date in patients with Lennox-Gastaut syndrome.
Apigenin, one of the predominant flavonoids in chamomile, was found to competitively inhibit the binding of flunitrazepam, a benzodiazepine derivative
, and was fitted into a pharmacophore model for ligands binding to the GABAA receptor benzodiazepine site.
Diazepam, first marketed as Vali-um is a benzodiazepine derivative
drug, used as a highly effective tranquilliser and sedative, It is commonly used for treating anxiety, stress, tension insomnia, seizures, alcohol withdrawal, muscle spasms tension and anxiety and in some surgical procedures to induce amnesia.
Since the benzodiazepine derivative
flunitrazepam (eg, in Rohypnol) has been used as a tool to incapacitate potential victims of, for example, robbery or rape, the pharmaceutical company Hoffmann La Roche mixes the Rohypnol tablets with the coloring agent indigo carmine to prevent its hidden admixture in beverages.