benzimidazole


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benz·im·id·a·zole

(benz-im-id-ā'zōl),
1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.

benzimidazole

(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)
n.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.

benzimidazole

A family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
 
Adverse effects
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.

benzimidazole

a group of compounds with anthelmintic properties. They all have the same central chemical structure—1,2-diaminobenzene. Some of the better known pharmaceutical compounds are thiabendazole, albendazole, cambendazole, fenbendazole, mebendazole, oxfendazole, oxibendazole and parbendazole.
References in periodicals archive ?
Factors affecting pharmacokinetics of benzimidazole anthelmintics in food-producing animals: the consequences and potential risks.
Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts.
Further, more samples need to studied for the complete picture of the genetic variation and drug resistant alleles in the benzimidazole drug-binding domain of [beta]-tubulin gene from W.
To summarise, albendazole, the newer benzimidazole derivative, is effective against most intestinal nematode and cestode infections and is, therefore, the drug of choice in mixed worm infection.
Over time, mushroom pathogens such as Verticillium fungicola, Cladobotryum mycophilum and now Trichoderma aggressivum have developed resistance to the benzimidazole fungicides (Fletcher &Yarham, 1976; Grogan & Gaze, 2000, Romaine et al, 2005).
1) USP 7,227,024 Method for the Synthesis of a Benzimidazole Compound *expires October 14, 2023)
TREANDA is a novel treatment with a unique chemical structure that is synthesized to combine an alkylating group and a purine-like benzimidazole component.
A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN).
Atlanta, GA) have patented asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole, found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences.
The final common pathway of the benzimidazole is thought to be inhibition of [beta]-tubulin polymerase, causing disruption of cytoplasmic microtubule formation.
ViroPharm says maribavir is a potent member of a new class of drugs called benzimidazole ribosides.
2]/g Stearic acid Octadecanoic acid beads Corax N550 Iodine absorption number 43, CTAB 42 Naugard 445 4,4'-Bis (a,a-dimethylbenzyl) diphenylamine Rhenogran Zinc methly mercapto ZMMBI 50 benzimidazole, 50% in EPDM/EVA binder Luperox F40 1,3 1,4-Bis(tert-butyl peroxy isopropyl) ben- zene 40% active on CaC[O.