Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CY2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning.
Workers exposed to benzene may potentially suffer chronic benzene poisoning (BP).
Benzene poisoning was diagnosed from 1980 to 1998 by the local authorized Occupational Disease Diagnostic Team, and patients were registered in the hospitals of prevention and treatment for occupational diseases, which cooperated with us.
Combined effect of CYP2E1, GSTT1, and NQO1 genetic polymorphisms on risks of benzene poisoning.
Indirect validation of benzene exposure assessment by association with benzene poisoning.
Diagnostic criteria and principles of management of occupational benzene poisoning (GB 3230-82).