monoclonal gammopathy of unknown significance

(redirected from benign monoclonal gammopathy)
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monoclonal gammopathy of unknown significance (MGUS),

a gammopathy diagnosed by electrophoresis of serum of asymptomatic old people who have no other evidence of plasma cell neoplasia; in 20% of cases it evolves into plasma cell malignancy.

mon·o·clo·nal gam·mop·a·thy of un·known sig·ni·fi·cance

(MGUS) (mon'ō-klōn'ăl gam-mop'ă-thē ŭn-nōn' sig-nif'i-kăns)
A gammopathy diagnosed by electrophoresis of serum of asymptomatic old people who have no other evidence of plasma cell neoplasia; in 20% of cases, it evolves into plasma cell malignancy.
Synonym(s): benign monoclonal gammopathy.
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References in periodicals archive ?
In these cases the presence of serum monoclonal immunoglobulin is usually considered a benign monoclonal gammopathy, but this diagnosis has been renamed "monoclonal gammopathy of undetermined significance" because long-term follow-up in these patients has shown a high risk (approximately 25%) for the development of myeloma or lymphoma.
Sidman and a research team at the Maine Cytometry Research Institute in Portland plan to test and follow the B-lymphocyte changes in several dozen patients with benign monoclonal gammopathy.
Inherited bisalbuminemia with benign monoclonal gammopathy detected by capillary but not agarose gel electrophoresis.
The present case of bisalbuminemia and benign monoclonal gammopathy appears to be the second description of such an association.
We used urine samples obtained from inpatients with multiple myeloma (n = 9), benign monoclonal gammopathy (n = 1), primary macroglobulinemia (n = 1), light chain deposition disease (n = 1), and primary amyloidosis (n = 5).

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