P413: Once-Daily Treatment with Beclomethasone
Dipropionate Nasal Aerosol Provides Long-Term and Sustained 24-Hour Nasal Symptom Relief in Patients with Perennial Allergic Rhinitis
Steroid doses ranged from 200 to 4000 mcg beclomethasone
equivalent ICS per day.
They were on one of three ICSs: large-particle fluticasone, large-particle beclomethasone
with a now-banned chlorofluorocarbon propellant, or ultrafine-particle beclomethasone
in a solution aerosol--that is, QVAR.
DOR's lead product, orBec (oral beclomethasone
dipropionate), is currently in a pivotal phase III clinical trial for the treatment of intestinal graft-vs.
Inhaled corticosteroids, especially beclomethasone
(Vanceril or Beclovent) or budesonide (Pulmicort) are the drugs of choice for persistent asthma not controlled by cromolyn or nedocromil.
And the results of a randomized trial of inhaled beclomethasone
compared with oral theophylline found similar rates of asthma exacerbation during pregnancy with the two drugs.
The patient's medications on admission included zalcitabine, lamivudine, saquinavir, trimethoprim/ sulfamethoxazole, clindamycin, ciprofloxacin, ganciclovir, senna, naproxen, beclomethasone
dipropionate, oxymetazoline HCl, morphine, potassium chloride, warfarin, and zolpidem.
Powdered formulations of popular asthma drugs, such as beclomethasone
dipropionate, fluticasone, salmeterol, and terbutaline sulphate are more acidic than aerosols.
orBec (oral beclomethasone
17,21-dipropionate or BDP) represents a first-of-its-kind oral, locally acting therapy tailored to treat the GI manifestation of chronic GVHD, the organ system where GVHD is most frequently encountered and highly problematic.
Rescue therapy with beclomethasone
combined with albuterol reduced the risk of exacerbations requiring oral corticosteroid treatment, even without daily steroid use, according to a placebo-controlled study of children and adolescents with mild persistent asthma.
which grants Sigma-Tau an exclusive right to negotiate terms and conditions for a possible business transaction or strategic alliance regarding orBec (oral beclomethasone
dipropionate or oral BDP) and potentially other DOR pipeline compounds until March 1, 2009.