bcr-abl oncoprotein

bcr-abl oncoprotein

A protein product of the fused BCR-ABLl oncogene produced by the Philadelphia chromosome, which plays a key role in initiating and maintaining leukaemia.
References in periodicals archive ?
Most importantly, the BCR-ABL oncoprotein provided, for the first time, a specific therapeutic target in hematologic malignancies.
The Bcr-Abl oncoprotein differs from the endogenous c-Abl protein in both its subcellular localization and its tyrosine kinase (TK) activity.
The Bcr-Abl oncoprotein is responsible for a wide range of human leukemias, including most cases of chronic myeloid leukemia (CML).