bcl-1

CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.

bcl-1

Proto-ONCOGENEs concerned with the persistence of LYMPHOCYTES. Mutations can cause various kinds of lymphocytic lymphomas and chronic lymphocytic leukaemia. bcl-1 genes are situated at chromocoam sites that break easily.
References in periodicals archive ?
Frequency of Bcl-1 genotypes in control and rheumatoid arthritis cases NR3C1 gene Rheumatoid arthritis Healthy OR (n=65) control (n=70) n % n % BCL-1 polymorphism Genotype CC 35 53.
For oral administration, BCL-1, 400 mg/kg; BCL-2, 800 mg/kg; BCL-3, 1600 mg/kg; BCL-4, 3200 mg/kg; BCL-5, 6400 mg/kg.
Inhibition of the cancer-related genes PKC-alpha, BCL-1 and c-RAF has been accomplished at Cytoclonal using the OASIS(TM) technology.
Cytoclonal has identified optimized inhibitor reagents to several human cancer related genes such as BCL-1, c-RAF and PKC-alpha.