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basophil

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basophil /ba·so·phil/ (ba´so-fil)
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. basophil´ic

ba·so·phil (bs-fl) or ba·so·phile (-fl)
n.
A cell, especially a white blood cell, having granules that stain readily with basic dyes.

Basophil
White blood cell that increases in response to parasitic infections and allergic reactions.

basophil
[bā′səfil]
Etymology: Gk, basis + philein, to love
a granulocytic white blood cell characterized by cytoplasmic granules that stain blue when exposed to a basic dye. Basophils represent 1% or less of the total white blood cell count. The relative number of basophils increases in myeloproliferative diseases and decreases in severe allergic reactions. An increase in number is seen during the healing phase of inflammation. Basophils produce histamine during inflammatory reactions. Also called basophilic erythrocyte. Compare eosinophil, neutrophil. See also agranulocyte, differential white blood cell count, granulocyte, leukocyte, polymorphonuclear leukocyte. basophilic, adj.

basophil,
n white blood cell with cytoplasmic granules and histamines used to direct other WBCs to inflamed areas.
Enlarge picture
Basophils.

basophil (bā´sfil),
basophil
1. any structure, cell or histological element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. a beta cell of the adenohypophysis.

basophil cell
a beta cell of the adenohypophysis which produces luteinizing and follicle stimulating hormones.
basophil degranulation test
an in vitro cellular test for immediate hypersensitivity; it detects degranulation of basophils, by their loss of affinity for staining, when blood from a hypersensitive dog is incubated with allergen extracts.

basophil
Basophilic granulocyte Hematology A type of granular WBC with large distinctly basophilic/“blue” 2º granules containing heparin, histamine, PAF and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high affinity Fc receptors on the cell surface


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Der p 1 induces production of proinflammatory cytokines in vitro [interletddn (IL)-8, IL-6, granulocyte-macrophage colony-stimulating factor] and induces IgE-independent mast cell and basophil degranulation (King et al.
Clumps of finely particulate basophil material were seen in H&E-stained sections of bacillary angiomatosis and subsequently identified as Bartonella (41).
The antibodies normally bind to and disrupt basophil membranes until the membranes can no longer hold a laboratroy stain, a process known as degranulation.
 
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