basophil


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Related to basophil: eosinophil, monocyte, lymphocyte

basophil

 [ba´so-fil]
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size; about 1 per cent bring anticoagulants to inflamed tissues. Called also basophilic leukocyte.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. Called also beta cell.

ba·so·phil

, basophile (bā'sō-fil, -fīl),
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic
3. A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell although they originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

/ba·so·phil/ (ba´so-fil)
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. basophil´ic

basophil

(bā′sə-fĭl, -zə-) also

basophile

(-fīl′, -fĭl)
n.
A cell, especially a white blood cell, having granules that stain readily with basic dyes.

basophil

[bā′səfil]
Etymology: Gk, basis + philein, to love
a granulocytic white blood cell characterized by cytoplasmic granules that stain blue when exposed to a basic dye. Basophils represent 1% or less of the total white blood cell count. The relative number of basophils increases in myeloproliferative diseases and decreases in severe allergic reactions. An increase in number is seen during the healing phase of inflammation. Basophils produce histamine during inflammatory reactions. Also called basophilic erythrocyte.Compare eosinophil,neutrophil.See also agranulocyte,differential white blood cell count,granulocyte,leukocyte. basophilic, adj.
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Basophil

basophil

A type of granular leukocyte with large, distinctly basophilic/“blue” secondary granules containing heparin, histamine, platelet-activating factor (PAF) and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high-affinity Fc receptors on the cell surface.

basophil

Basophilic granulocyte Hematology A type of granular WBC with large distinctly basophilic/“blue” 2º granules containing heparin, histamine, PAF and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high affinity Fc receptors on the cell surface

ba·so·phil

, basophile (bā'sō-fil, -fīl)
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic.
3. A phagocytic leukocyte of the blood characterized by basophilic granules containing heparin and histamine; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell, although the two cell types originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

Having an affinity for alkali. The term is used conveniently to refer to the group of blood white cells (leukocytes) whose internal granules take up an alkaline stain. The granules in basophils are mainly histamine and it is the release of this powerful chemical that causes most of the trouble in allergy. Basophils closely resemble tissue MAST CELLS.

Basophil

White blood cell that increases in response to parasitic infections and allergic reactions.

basophil

a granular white blood cell (leukocyte) that takes up non-acidic stains

basophil,

n white blood cell with cytoplasmic granules and histamines used to direct other WBCs to inflamed areas.
Enlarge picture
Basophils.

ba·so·phil

, basophile (bā'sō-fil, -fīl)
A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines.
[baso- + G. philēo, to love]

basophil (bā´səfil),

basophil

1. any structure, cell or histological element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, relatively pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size.
3. a beta cell of the adenohypophysis.

basophil cell
a beta cell of the adenohypophysis which produces luteinizing and follicle stimulating hormones.
basophil degranulation test
an in vitro cellular test for immediate hypersensitivity; it detects degranulation of basophils, by their loss of affinity for staining, when blood from a hypersensitive dog is incubated with allergen extracts.
References in periodicals archive ?
3]/[micro]L Heterophils, % 71 [+ or -] 13 74 35-85 Lymphocytes, % 23 [+ or -] 12 21 6-55 Eosinophils, % 0 [+ or -] 0 1 0-1 Monocytes, % 0 [+ or -] 0 0 0-3 Basophils, % 0 [+ or -] 0 0 0-5 Heterophil: lymphocyte 3.
32 Regression ns ns Doses of propolis residue Basophil Monocyte Control 8.
Omalizunab binds to IgE and prevents it from attaching to its receptors on the mast cells and basophils, thus inhibiting activation of type 1 hypersensitivity.
Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity.
The smaller cell populations (eosinophils, basophils and blast cells) showed less variation in the results between the the manual and DM96 methods, however, these did not correlate well with the Sysmex data, the eosinophil population being the exception.
A significant decrease in blood basophils in females was also seen with both UFP concentrations (exposure-sex interaction, p = 0.
2010; 2011) reported QTL for TLR9, an immunity related element in gut, at 0 to 47 cM and for IFNG at 47 to 93 cM on SSC16 in a Duroc x Pietrain cross, where the QTL for basophil was also detected at 42 Mb in this study (Table 3).
In acute allergic conditions, serum mast cell [beta] triptase (>1ng/ml) or plasma histamine (>10 nmol/L) levels which suggest mast cell or basophil activation can be determined (36).
Using an animal-based model of allergic inflammation in the lung that shares characteristics with asthma in humans, they found that antibiotic treatment resulted in significantly elevated basophil responses and a marked increase in the amount of basophil-mediated allergic airway inflammation.
Gell-Coombs classification system GELL-COOMBS TYPE OF IMMUNOPATHOLOGICAL POSSIBLE CLASSICIFICATION RESPONSE MECHANISM TESTING Type I IgE-Mediated Mast Cell/Basophil Basophil Degranulation Histamine Release Leukotriene Type II IgG Response FcR Dependent Cell Drug-Specific Destruction IgG Type III IgG/IgM Immune Complex Drug-Specific Deposition IgG Type IV T Cell (Th1) Monocyte T Cell Activation-IFN-[gamma] Activation T Cell (Th2) Eosinophilic Inflammation (IL5, IL4) T Cell (CTL) CD4/CD8 - Perforin/Granzyme B T Cells Neutrophil Recruitment (IL8)
Total WBC count was 2500/[micro]l neutrophil 32 per cent, lymphocyte 60 per cent, basophil 3 per cent, monocyte 5 per cent, eosinophil 0 per cent, Hb 4g/dl, platelet count 10,000/[micro]l only on the day of admission (all determined on autoanalysed blood cell counter of MERCK, Germany).