baseline imbalance

baseline imbalance

A term of art for a systematic error in creating intervention groups in a clinical trial, such that participants differ with respect to prognosis—i.e., the groups differ in baseline characteristics because of the way in which the participants were selected or assigned—or because the participants are not representative of the population from which they were selected.
References in periodicals archive ?
There was an unexpected highly significant baseline imbalance in the percentage of placebo versus citicoline-treated patients who had mild strokes on study entry (34 percent for placebo vs.
More specifically, only when statistical adjustments were performed to correct significant baseline imbalances in the DES and BMS groups, and analysis was confined to a time window from six months to three years, did the Swedish study group identify a slightly higher risk ratio for death in the DES group.
Adding to the several analyses in the literature that attempt to use traditional means to take into account baseline imbalances in (the NINDS-TPA trials), this entirely complementary and novel approach of sliding dichotomy also shows robust treatment effects," Dr.
Full browser ?