base excision repair


Also found in: Acronyms, Encyclopedia, Wikipedia.

base excision repair

A mechanism that repairs damaged DNA during the cell cycle by removing small, non-helix-distorting nucleotide base lesions, which could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases that recognise and remove damaged or inappropriate bases, forming AP sites which are then cleaved by an AP endonuclease. The single-strand break formed by AP endonuclease are then processed by either short-patch (a single nucleotide is replaced), or long-patch (2–10 new nucleotides are synthesised) repair.
References in periodicals archive ?
Mechanistic insight into DNA damage and repair in ischemic stroke: Exploiting the base excision repair pathway as a model of neuroprotection.
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites," The EMBO Journal, vol.
Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene.
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations.
Cells normally use base excision repair to fix oxidative damage to DNA caused by reactive molecules such as hydrogen peroxide and oxygen radicals, which form during energy production and other metabolic processes.
Recent advances indicate DNA base excision repair (BER) protein, i.
Oxidative DNA damage and decreased DNA base excision repair function in injured neurons occur as early as 30 minutes after onset of reperfusion in cerebral ischemia [48-52].
According to the company, TRC102 is a novel small molecule inhibitor of the base excision repair (BER) pathway of chemotherapy resistance and is being studied in multiple ongoing clinical trials in combination with multiple chemotherapeutics.
In this process, base excision repair pathways may play a predominant role in protecting both nuclear and mitochondrial DNA from radiation damages.
Because base excision repair (BER) is the predominant pathway involved in repairing oxidative damage, Barry et al.