base excision repair


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base excision repair

A mechanism that repairs damaged DNA during the cell cycle by removing small, non-helix-distorting nucleotide base lesions, which could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases that recognise and remove damaged or inappropriate bases, forming AP sites which are then cleaved by an AP endonuclease. The single-strand break formed by AP endonuclease are then processed by either short-patch (a single nucleotide is replaced), or long-patch (2–10 new nucleotides are synthesised) repair.
References in periodicals archive ?
Overall, our findings indicate that HIV infection and integration efficiency depends on the presence of base excision repair proteins, and that these proteins might make novel new targets for the treatment of HIV infection," Yoder says.
Conclusions: Base excision repair proteins along with regulating MAPK may be useful for repairing oxygen damage in lung cells.
Selection of gene and SNP for cancer association study: The gene OGG1 was chosen for the study mainly on the basis of its crucial role in the DNA repair process, especially the base excision repair (BER) pathway.
Our results support the thesis that the great majority of oxidatively damaged DNA is removed via the base excision repair pathway (24-26).
Since DNA damage that is caused by pemetrexed is repaired by Base Excision Repair (BER) and since lucanthone inhibits AP endonuclease, a key component of BER pathway, it is hypothesized that lucanthone will potentiate the activity of pemetrexed.
Base excision repair (BER) pathway, one of the major defense mechanisms, is generally considered to constitute the primary defense against lesions generated by ionizing radiation and strong alkylating agents as well as by endogenous DNA-damaging agents.
Inhibition of the ligation step in base excision repair (Li and Rossman 1989) by arsenite has also been reported.