basaloid carcinoma

cloacogenic carcinoma

1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca.
2. in oncology, anal cancer arising proximal to the pectinate line.
[cloaca + -genic]

basaloid carcinoma

[bā′səloid]
Etymology: Gk, basis + eidos, form, karkinos, crab, oma, tumor
a rare transitional malignant neoplasm of the anal canal containing areas that resemble basal cell carcinoma of the skin. Basaloid carcinoma is rapidly invasive. Tumor may spread to the skin of the perineum.

basaloid carcinoma

Gastrointestinal
A subtype of squamous cell carcinoma arising at the anorectal transition zone, which comprises 20% of all anal carcinomas. It is linked to HPV infection and more common in homosexual males, implicating anal intercourse as a vector. It has been variously reported as having either a better or worse prognosis than standard anal cancer.
 
Lung
A form of large cell carcinoma (non-small cell type), in which at least 50% of the cellular component is a basal cell carcinoma; it is often high-grade with 15–50 mitoses/10 HPF, and has a dismal prognosis by some authors as a type of squamous cell carcinoma.

IHC
p63, CK 5/6 +ve.

DiffDx
Poorly differentiated squamous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma.
 
Pattern
Small cuboidal or fusiform cells; lobular or tentacular invasion, peripheral palisading.
 
Prognosis
Probably worse than stage-matched squamous cell carcinoma.

Oral
Aggressive, rapidly growing; nodes are involved in 2/3 at time of diagnosis; distant metastases frequent (37–50%); age/site/stage/treatment matched-case control studies have the same prognosis as high-grade conventional SCC.
References in periodicals archive ?
For example, immunohistochemical stains Bcl-2 and Ki-67 are reportedly helpful in distinguishing basaloid carcinoma from benign basal cell lesions of the prostate gland.
Cases with a diagnosis of small cell carcinoma, mixed non-small cell and small cell lung carcinoma, giant cell carcinoma, mucoepidermoid carcinoma, sarcomatoid carcinoma, and basaloid carcinoma were excluded.
Histologic subtyping of anal squamous cell carcinomas was once recommended by the WHO, (27) and the categories included large-cell keratinizing squamous carcinoma, large-cell nonkeratinizing squamous carcinoma, and basaloid carcinoma.
Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma.
Squamous cell carcinoma and basaloid carcinoma can be differentiated from SNUC by the absence of keratinization in SNUC.
To test the utility of this protocol, we identified 3 additional cases of basaloid carcinoma, of unknown primary, metastatic to neck lymph nodes (Table 5).
The basaloid variant of squamous cell carcinoma has a stronger argument for retention because there is evidence that it carries a poorer prognosis, (16) although the relationship between this lesion and basaloid carcinoma (currently a large cell variant) is open to question.
Adenoid cystic" and basaloid carcinomas of the ovary: evidence for a surface epithelial lineage.
Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck.
Warty or basaloid carcinomas are related to the presence of HPV, genital warts, and warty and basaloid VIN, and occur in younger women.
Several additional histologic types of SGC were examined in this study, (18) including apocrine, hidradenocarcinoma, mucinous, and basaloid carcinomas, which were not included in our study.
In one report by Ohtaka et al, (6) sarcomatoid carcinoma of the esophagus had squamous and basaloid carcinomas that were accompanied by a spindle cell proliferation.