basal cell nevus

ba·sal cell ne·vus

a hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-colored papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma; also noted are punctate keratotic lesions of the palms and soles; the lesions usually remain benign, but in some cases ulceration and invasion occur and are evidence of malignant change; autosomal dominant inheritance; caused by mutation in the human PTCH, the homologue of the "patched gene" of Drosophila. PTCH is found on chromosome 9q22.

ba·sal cell ne·vus

(bā'săl sel nē'vŭs)
A hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as flesh-colored papules histologically indistinguishable from basal cell epithelioma; the lesions usually remain benign, but in some cases malignant change occurs.

ba·sal cell ne·vus

(bā'săl sel nē'vŭs)
A hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-colored papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma.
References in periodicals archive ?
COPENHAGEN -- A glimpse into the massive burden imposed upon patients with basal cell nevus syndrome (BCNS) is provided by the initial report from the first U.
Gorlin syndrome or basal cell nevus syndrome (BCNS): A case report.
The second publication, entitled "Inhibiting the Hedgehog Pathway in Patients with Basal-Cell Nevus Syndrome," reports on results from an investigator-sponsored study evaluating the potential of Erivedge in 41 patients with basal cell nevus syndrome (BCNS) and surgically eligible BCCs.
NEW ORLEANS -- An oral inhibitor of the hedgehog pathway proved effective for the treatment and prevention of basal cell carcinomas in patients with basal cell nevus syndrome in a phase II study.
1) It may be associated with Gorlin-Goltz basal cell nevus syndrome, a rare autosomal dominant condition characterised by multiple nevoid basal cell carcinomas, jaw cysts and bifid ribs.
Summary: TEHRAN (FNA)- Scientists say that patients with basal cell nevus syndrome, which predisposes them to develop non-melanoma skin cancers, appear to be at increased risk for vitamin D deficiency if they take steps to protect themselves from sunlight.
Patients with basal cell nevus syndrome-which might lead to non-melanoma skin cancers-are at a higher risk for vitamin D deficiency if they take steps to protect themselves from sunlight.
Twenty-four trials, in progress or recruiting, focus on GDC-0449's safety and efficacy in a variety of cancers, including basal cell nevus syndrome, and pancreatic, gastrointestinal, lung, breast, and brain cancers.
In addition, Genentech and Roche continue to work with clinical investigators to evaluate GDC-0449 in other diseases with Hedgehog-pathway mutations such as medulloblastoma, a childhood brain cancer (in studies sponsored by the National Cancer Institute) and in BCCs in basal cell nevus (Gorlin) syndrome, a rare genetic disorder in which patients typically develop multiple BCCs over their lifetime, added Passeri.
Other risk factors include arsenic, coaltar, chimney smoke, chronic skin irritation, chronic inflammation, xeroderma pigmentosum, and basal cell nevus syndrome.

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