basal cell nevus

ba·sal cell ne·vus

a hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-colored papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma; also noted are punctate keratotic lesions of the palms and soles; the lesions usually remain benign, but in some cases ulceration and invasion occur and are evidence of malignant change; autosomal dominant inheritance; caused by mutation in the human PTCH, the homologue of the "patched gene" of Drosophila. PTCH is found on chromosome 9q22.

ba·sal cell ne·vus

(bā'săl sel nē'vŭs)
A hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as flesh-colored papules histologically indistinguishable from basal cell epithelioma; the lesions usually remain benign, but in some cases malignant change occurs.

ba·sal cell ne·vus

(bā'săl sel nē'vŭs)
A hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-colored papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma.
References in periodicals archive ?
The second publication, entitled "Inhibiting the Hedgehog Pathway in Patients with Basal-Cell Nevus Syndrome," reports on results from an investigator-sponsored study evaluating the potential of Erivedge in 41 patients with basal cell nevus syndrome (BCNS) and surgically eligible BCCs.
NEW ORLEANS -- An oral inhibitor of the hedgehog pathway proved effective for the treatment and prevention of basal cell carcinomas in patients with basal cell nevus syndrome in a phase II study.
1) It may be associated with Gorlin-Goltz basal cell nevus syndrome, a rare autosomal dominant condition characterised by multiple nevoid basal cell carcinomas, jaw cysts and bifid ribs.
Summary: TEHRAN (FNA)- Scientists say that patients with basal cell nevus syndrome, which predisposes them to develop non-melanoma skin cancers, appear to be at increased risk for vitamin D deficiency if they take steps to protect themselves from sunlight.
Patients with basal cell nevus syndrome-which might lead to non-melanoma skin cancers-are at a higher risk for vitamin D deficiency if they take steps to protect themselves from sunlight.
Elmets explained that this oral medication has been shown to be an effective chemopreventive agent in patients with a syndrome known as basal cell nevus syndrome.
Basaloid follicular hamartoma in a linear distribution may mimic linear epidermal nevus, lichen striatus, linear morphea, and basal cell nevus.
We are concerned that their diagnosis is incorrect, and that the patient rather has a linear basal cell nevus.
For example, scientists recently discovered that mutations in the human version of a gene that controls fruit fly growth and development are the likely cause of both the basal cell nevus syndrome, a rare inherited disorder, and sporadic basal cell carcinoma of the skin, the most common human cancer.
In addition to skin cancer, mutations in the human version of patched result in basal cell nevus syndrome, a rare condition in which affected individuals suffer various cancers, including, often, hundreds of basal cell carcinomas, and developmental defects such as fused ribs, extra digits, spina bifida, and oversized heads.
Both groups were seeking the source of a rare - but virulent - related disease known as basal cell nevus syndrome, which mostly affects children who have been exposed to the sun.
Announced promising interim results from investigator-initiated Phase II study of vismodegib; data shows effect in prevention and treatment of BCC in Basal Cell Nevus Syndrome patients

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