ballooning degeneration

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Related to ballooning degeneration: feathery degeneration

bal·loon·ing de·gen·er·a·tion

an obsolete term for cells that are infected with certain viruses, resulting in conspicuous swelling of the cell and cytoplasmic vacuolation.
Hepatology A histologic change seen in hepatocytes infected with HAV and HBV; the cells have abundant pale granular cytoplasm; the ‘ground-glass’ granularity of the cells corresponds to viral particles
Neuropathology A descriptive term for the histologic changes of vincristine therapy-induced peripheral neuropathy, enhanced by VP-16


deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration. See also wallerian degeneration, Zenker's necrosis.

albuminoid degeneration
cloudy swelling, an early stage of degenerative change characterized by swollen, parboiled-appearing tissues which revert to normal when the cause is removed.
ballooning degeneration
swelling of the cytoplasm in epidermal cells without vacuolization, enlarged or condensed nuclei and acantholysis. A characteristic of viral infections of the skin. Called also koilocytosis.
caseous degeneration
colloid degeneration
degeneration with conversion of the tissues into a gelatinous or gumlike material.
cystic degeneration
degeneration with formation of cysts.
fatty degeneration
deposit of fat globules in a tissue.
feathery degeneration
said of hepatocytes; a hydropic change in hepatocytes which have suffered long-term exposure to cholestasis.
fibrinoid degeneration
deposition or replacement with eosinophilic fibrillar or granular substance resembling fibrin.
fibroid degeneration
degeneration into fibrous tissue.
hyaline degeneration
a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histological appearance of tissues. Called also hyalinosis.
hydropic degeneration
see hydropic degeneration.
macular degeneration
degenerative changes in the macula retinae.
mucoid degeneration
degeneration with increased mucin which can be epithelial or mesenchymal in origin.
mucous degeneration
degeneration with accumulation of mucus in epithelial tissues. Called also myxomatous degeneration.
myxomatous degeneration
see mucous degeneration (above).
reticular degeneration
extreme intracellular edema of epidermal cells, resulting in rupture and multilocular intraepidermal vesicles with septae formed by the remaining cell walls. Seen in acute inflammatory dermatoses.
spongy degeneration
on microscopic examination has the physical appearance of a sponge. Usually applied to tissue of the central nervous system, caused by the loss of myelin.
References in periodicals archive ?
Histopathologically, infected epithelial cells showed prominent ballooning degeneration and dense, eosinophilic, cytoplasmic granules that were difficult to distinguish from keratohyalin bodies.
Within all epidermal layers, a moderate number of keratinocytes exhibited ballooning degeneration of the cytoplasm (Fig 3).
Epithelial debris, necrotic cells, and colonies of bacteria surrounded the cell clusters, and marked epidermal and dermal hyperplasia were observed along with ballooning degeneration (Fig 1).