The differential diagnostic considerations of a clear cell lesion in the skin are broad and include melanocytic lesions (balloon cell nevus or balloon cell melanoma), epithelial neoplasms (benign adnexal neoplasm and carcinoma with clear cells), xanthomas, and various mesenchymal neoplasms (eg, perivascular epithelioid cell tumor or clear cell sarcoma; Table 1).
Balloon cell nevi (Figure 4, A) and cellular blue nevi (Figure 4, B) may be distinguished from CCM using the same criteria that distinguish nevi from conventional melanoma, such as the absence of both nuclear atypia and dermal mitoses.
Metastatic balloon cell malignant melanoma: a case report and literature review.
3 Mostly, RCC with cutaneous metastases are clear cell type, so microscopic differential diagnosis are xanthoma, xanthelasma, sebaceous tumours, balloon cell
nevus, clear cell hydradenoma and other skin lesions characterized by the presence of clear cells.
Most variants of cutaneous nevi including combined nevus, balloon cell nevus, Spitz nevus, pigmented spindle cell nevus, and blue nevus have been reported in the conjunctiva.
Conjunctival melanoma can be composed of 1 (or different proportions) of 4 different cell types: small polyhedral cells, epithelioid cells, balloon cells, and spindle cells.
His viral culture was negative for VZV and HSV Histopathologic examination revealed an intraepidermal vesicle containing balloon cells
and multinucleated epithelial cells with reticular degeneration and a dense infiltration of lymphocytes, histiocytes, and neutrophils around the vesicle and superficial blood vessels.
Balloon cells develop in any damaged mucosa, but in the absence of other more characteristic features of GERD, they may be the only clue that a chemical injury has occurred.
The presence of balloon cells serves as an early esophageal mucosal marker of chemical injury but is not specific for it.