evolved to infect insect cells, human cells don't recognize the promoter sequences within their genome, so those genes are not expressed and the virus can't replicate.
With an eye to worldwide marketing, several companies are developing technology to mass-produce baculoviruses
in cultures of insect cells rather than in whole insects.
are a class of large, double-stranded DNA viruses that infect only invertebrate hosts and have been developed as environmentally safe biological control agents (Park et al.
of Waterloo, Canada) present nine papers discussing horticultural applications of plant genetic engineering, the role of microorganisms in recombinant DNA technology and synthetic biology, plant growth promoting rhizobacteria, mycorrhizal symbiosis, application of arbuscular mycorrhizal fungi in the production of fruits and ornamental crops, molecular biology of and advances in the development of baculoviruses
as biological pest control agents, natural antimicrobials to improve storage and shelf life of horticultural and agricultural products, and mycotoxins in fruits and fruit-derived products.
However, expression of either VP 1 or both VP 1 and VP2 with recombinant baculoviruses
formed viruslike particles that are morphologically and antigenically similar to the native virion (2).
Like many other researchers, Drezen had thought that the symbiotic viruses found in the braconid wasps were probably related to baculoviruses
, which are common in insects and have capsules shaped like those of the symbiotic viruses.
No one has looked into using baculoviruses
for mosquito control in 25 years.
Until now the use of baculoviruses
to transfer genes in mammalian systems has not been successful as they are immediately broken down by the immune system when they come into contact with serum.
Under the terms of the agreement, SmithKline Beecham was granted a non-exclusive license to the recombinant Hepatitis E virus ORF2 capsid genes cloned into baculoviruses
for commercial development, manufacturing, and marketing of Hepatitis E virus vaccines.
Construction of recombinant plasmid pVL1392 transfer vectors and generation of recombinant hK2 baculoviruses
When these genetically engineered baculoviruses
are used to infect insect cell cultures, these cells are "programmed" to manufacture the desired proteins.
The genome sequence and evolution of baculoviruses