babesiosis

Babesiosis 

Definition

Babesiosis is an infection of red blood cells caused by the single-celled parasite, Babesia microti, which is spread to humans by a tick bite.

Description

Babesiosis is a rare, tick-transmitted disease that is caused most often by the single-celled parasite Babesia microti. By 1995, fewer than 500 cases of babesiosis had been reported in the United States. The disease occurs primarily in New England and New York, especially on the coastal islands. However, cases have occurred in other parts of the United States. Because of tick activity, the risk for babesiosis is highest during June and July.

Ticks are small, blood-sucking arachnids. Although some ticks carry diseasecausing organisms, most do not. Babesia microti is spread to humans through the bite of the tick Ixodes scapularis (also called Ixodes dammini). Ixodes scapularis, called the "blacklegged deer tick," usually feeds on deer and mice. A tick picks up the parasites by feeding on an infected mouse and then passes them on by biting a new host, possibly a human. To pass on the parasites, the tick must be attached to the skin for 36-48 hours. Once in the bloodstream, Babesia microti enters a red blood cell, reproduces by cell division, and destroys the cell, causing anemia. Humans infected with Babesia microti produce antibodies that can be helpful in diagnosing the infection.

Causes and symptoms

Babesia microti live and divide within red blood cells, destroying the cells and causing anemia. The majority of people who are infected have no visible symptoms. In those who become ill, symptoms appear one to six weeks following the tick bite. Because the ticks are small, many patients have no recollection of a tick bite. The symptoms are flu-like and include tiredness, loss of appetite, fever, drenching sweats, and muscle pain. Nausea, vomiting, headache, shaking chills, blood in the urine, and depression can occur.

Persons who are over 40 years old, have had their spleen removed (splenectomized), and/or have a serious disease (cancer, AIDS, etc.) are at a greater risk for severe babesiosis. In severe cases of babesiosis, up to 85% of the blood cells can be infected. This causes a serious, possibly fatal, blood deficiency.

Diagnosis

Babesiosis can be diagnosed by examining a blood sample microscopically and detecting the presence of Babesia microti within the blood cells. The blood can also be checked for the presence of antibodies to the parasite.

Treatment

In serious cases, babesiosis is treated with a combination of clindamycin (Cleocin) and quinine. Clindamycin is given by injection and quinine is given orally three to four times a day for four to seven days. To reduce the number of parasites in the blood, severely ill patients have been treated with blood transfusions.

Prognosis

Otherwise healthy patients will recover completely. Babesiosis may last several months without treatment and is a severe, potentially fatal disease in splenectomized patients.

Prevention

The only prevention for babesiosis is to minimize exposure to ticks by staying on trails when walking through the woods, avoiding tall grasses, wearing long sleeves and tucking pant legs into socks, wearing insect repellent, and checking for ticks after an outing. Remove a tick as soon as possible by grasping the tick with tweezers and gently pulling. Splenectomized people should avoid northeastern coastal regions during the tick season.

Resources

Other

Mayo Clinic Online. March 5, 1998. http://www.mayohealth.org.

Key terms

Anemia — A below normal number of red blood cells in the bloodstream.

Parasite — An organism that lives upon or within another organism.

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babesiosis /ba·be·si·o·sis/ (bah-be″ze-o´sis) a group of tickborne diseases due to infection with species of Babesia, seen in wild and domestic animals associated with anemia, hemoglobinuria, and hemoglobinemia; it may spread to humans as a zoonosis that resembles malaria.

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ba·be·si·o·sis (b-bz-ss) or bab·e·si·a·sis (bb-z-ss)

n.

A human protozoan disease of the red blood cells caused by infection with a species of Babesia that is transmitted by ticks and characterized by fever, malaise, and hemolytic anemia. Also called piroplasmosis.

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babesiosis

[bəbē′sē·ō′sis]

Etymology: Victor Babés, Romanian bacteriologist, 1854-1926

a potentially severe and sometimes fatal disease caused by infection with protozoa of the genus Babesia. The parasite is introduced into the host through the bite of ticks of the species Ixodes dammini and infects red blood cells. In the United States, incidence of the disease is highest in the Northeast and North Central regions. Symptoms include headache, fever, chills, vomiting, hepatosplenomegaly, hemolytic anemia, fatigue, myalgia, and hemolysis. Treatment is clindamycin or quinone. Most patients with babesiosis are asymptomatic. Approximately 25% of patients with babesiosis are also infected with Lyme disease. Also called babesiasis [bab′əsī′əsis] .

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babesiosis [bah-be″ze-o´sis]

a group of tickborne diseases due to infection with protozoa of the genus Babesia, usually seen in wild or domestic animals as a type of anemia; it may spread to humans as a zoonosis characterized by a malarialike fever with chills, sweats, myalgia, nausea and vomiting, hemolytic anemia, and splenomegaly.

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babesiosis (bbē´zēo´-sis),

n a disease caused by
B. microti that is evidenced by malaria-like symptoms. Also called
babesiasis or
piroplasmosis.

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babesiosis

a group of diseases caused by the protozoan Babesia spp. and transmitted by blood-sucking ticks. Clinically they are all characterized by fever and intravascular hemolysis manifested by a syndrome of anemia, hemoglobinuria and jaundice. Called also tick fever, Texas fever, redwater fever.

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babesiosis

Infectious disease A systemic infection caused by Babesia spp, in particular B microti; in Nantucket, an endemic region, ±40% of I dammini have B microti sporozoites in their saliva Clinical 1-4 wk incubation, fever, shaking chills, malaise myalgias, fatigue, hemoglobinuria Treatment Clindamycin, quinine. See Babesia microti.