NCOA1

(redirected from bHLHe74)

NCOA1

A gene on chromosome 2p23 that encodes a protein of the p160/steroid receptor coactivator family, which acts as a transcriptional coactivator for steroid and nuclear hormone receptors, coactivating different nuclear receptors—e.g., PGR, GR and ER, retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors, and may participate in chromatin remodelling and recruitment of general transcription factors. NCOA1 acts with NCOA2 to control energy balance between white and brown adipose tissues.