SREBF2

(redirected from bHLHd2)

SREBF2

A gene on chromosome 22q13 that encodes a ubiquitously expressed transcription factor with a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain, which controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The cognate gene product is required for lipid homeostasis: it regulates transcription of the LDL receptor gene, cholesterol and the fatty acid synthesis pathway.