WDR34

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WDR34

A gene on chromosome 9q34.11 that encodes a member of the WD-repeat protein family, which are involved in various cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. WDR34 is a negative regulator of the Toll-like and IL-1R receptor-signalling pathways. It inhibits the MAP3K7-induced NF-kappa-B activation pathway, and inhibits MAP3K7 phosphorylation.