Identification of cell abnormalities--such as the large azurophilic
granules in toxic granulation, asynchronous maturation, micromegakaryocyte identification or quantitating variant lymphs--still requires a skilled human eye.
MPO, an enzyme found predominantly in the azurophilic
granules of neutrophils, is a biochemical marker of neutrophil infiltration, and measurements of its activity have been widely used to detect intestinal inflammatory processes (Yamada et al.
Myeloperoxidase (MPO) is an enzyme found primarily in the azurophilic
granules of neutrophils and has been used extensively as a biochemical marker of granulocyte infiltration in various tissues.
Electron microscopic studies suggest that these granules are formed by the fusion of azurophilic
Myeloperoxidase is an enzyme that is found predominantly in the azurophilic
granules of polymorphonuclear leukocytes (PMN).
The t(8; 21) subtype is characterized by large blasts with abundant basophilic cytoplasm, with perinuclear clearing or hofs, and numerous azurophilic
Mitotic figures are easily found, and Giemsa-stained touch preparations commonly highlight the azurophilic
granules within the cytoplasm, which resemble those found in normal NK cells (3).
1,2) The appearance of TG is the result of an increase in acid mucosubstance in azurophilic
granules, which stains more prominently than under normal circumstances.
Activity of tissue MPO, an enzyme that is found predominantly in the azurophilic
granules of polymorphonuclear leukocytes, correlates with the number of polymorphonuclear neutrophils determined histochemically in the inflamed tissues; it is therefore used as an indication of tissue neutrophil accumulation.
granules were also seen in the cytoplasm.
These candidates include nuclear proteins (histone Hl, a 50-kDa myeloid cell-specific nuclear envelope protein, and HMG-1 and HMG-2, nonhistone chromosomal proteins), cytoplasmic proteins ([alpha]-enolase and catalase), and proteins present in the ([BETA]- and azurophilic
granules (lactoferrin, ([BETA]-glucuronidase, lysozyme, elastase, cathepsin G, and bacterial/permeability-increasing [BPI] protein).
It has been also observed that increased myeloperoxidase which is present in azurophilic
granules of polymorphonuclear neutrophils, activity in periodontitis as compared to controls .