azurophilic

azurophilic

 [azh″u-ro-fil´ik]
staining with azure or similar blue aniline dyes.

azurophil(e)

(ăz-ū′rō-fĭl) [″ + Gr. philein, to love]
Staining readily with azure dye.
azurophilic (ăz-ū′rō-fĭl′ĭk), adjective

azurophilic

staining with azure or similar metachromatic thiazine dyes; pertaining to azurophilia.

azurophilic granules
the large, homogeneous, dense, peroxidase-positive granules of progranulocytes and early myelocytes that stain blue with Romanowsky stains because of their acid mucopolysaccharide content. Called also primary granules.
References in periodicals archive ?
ANCAs are auto-antibodies directed against azurophilic proteins within neutrophils, including perinuclear ANCAs (p-ANCAs) and cytoplasmic ANCAs.
Diagnosis can be made with a simple peripheral smear for the classic giant azurophilic granules, which are peroxidase-positive, in all granule-containing cells including the peripheral blood and bone marrow.
The urine strip test for white blood cells detects leucocyte esterase, which is present in azurophilic granules of leucocytes.
Myeloperoxidase is an enzyme found in azurophilic granules of neutrophils (and less in monocytes) that also contain heme, but rather than being red-brown, it is yellow-green.
MPO is abundantly stored and expressed in primary azurophilic granules of neutrophils.
Azurophilic (primary) granules contain MPO, defensins, and proteinases.
MPO, a member of the heme peroxidase superfamily, is contained in azurophilic granules in neutrophils and monocytes.
Myeloperoxidase is a 150-165-kDa molecule synthesized during myeloid differentiation that constitutes the major component of the neutrophil azurophilic granules.
Identification of cell abnormalities--such as the large azurophilic granules in toxic granulation, asynchronous maturation, micromegakaryocyte identification or quantitating variant lymphs--still requires a skilled human eye.
In order to confirm the cellular response in the collected synovial fluid after zymosan injection (6h), it was also determined the MPO activity, an enzyme found primarily in the azurophilic granules of the neutrophils and has been widely used as a biochemical marker of granulocyte infiltration into various tissues.