aztreonam


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Related to aztreonam: gentamicin

aztreonam

 [az´tre-o-nam″]
a narrow-range antibiotic effective against aerobic gram-negative bacteria; used for the treatment of infections caused by susceptible organisms. Administered intravenously or intramuscularly.

aztreonam

/az·tre·o·nam/ (az´tre-o-nam″) a narrow-range monobactamantibiotic effective against aerobic gram-negative bacteria.

aztreonam

(ăz-trē′ə-năm′)
n.
A synthetic antibiotic, C13H17N5O8S2, that acts against a wide spectrum of gram-negative bacteria.

aztreonam

A BETA-LACTAM antibiotic effective against aerobic GRAM NEGATIVE organisms. A brand name is Azactam.

aztreonam

a monobactam, β-lactam antibiotic, very resistant to β-lactamase, but with a narrow range of activity. It is used parenterally against infections with gram-negative organisms, particularly Pseudomonas aeruginosa.
References in periodicals archive ?
mipenem 4 1,6 9 3,1 6 2,1 Trimetoprim 133 54,1 168 57,1 136 48,0 sulfometaksazol Aztreonam 78 31,7 100 34,0 68 23,6 Seftazidim 67 27,2 95 32,3 103 35,8 Tobramisin 107 43,5 201 68,4 208 72,2 Norfloksasin 65 26,4 171 58,2 178 61,8 Nitrufurantoin 57 23,2 134 45,6 230 79,9 2007 (n=429) 2008 (n=389) Ortalama Sayi Direnc Sayi Direnc Direnc (%) (%) (%) (%) Ampisilin 265 61,8 294 75,6 80,8 Sefazolin 226 52,7 153 39,3 43,6 Gentamisin 157 36,6 108 27,8 30,0 Amikasin 31 7,2 10 2,6 6,2 Amoksisilin 267 62,2 173 44,5 54,8 klavulanat Sefuroksim 232 54,8 136 34,9 47,4 Sefepim 182 42,4 120 30,8 33,2 Sefotaksim 186 43,3 120 30,8 36,6 Siproflfoksasin 285 66,4 141 36,2 57,0 Levofloksasin 285 66,4 139 35,7 52,4 ?
One strain tested on the NBC41 showed resistance to aztreonam, cefotaxime, ceftriaxone, and ceftazidime, but was not presumptively identified as an ESBL by the NBPC30 panel.
So we analysed carbapenems, ceftazidime and aztreonam as phenotypical indicator substrates of [beta]-lactamases (2) in the strains of both origin.
Each 2 mL single use glass vial contains 75 mg of lyophilized aztreonam and must be mixed with the provided 1 mL of sterile diluent (0.
1 R 6 Norfloxacin (Nf 10) No zone R 7 Aztreonam (Az 30) No zone R 8 Ceftazidime (Ca 30) 13.
The authors concluded that tigecycline is not inferior to vancomycin and aztreonam for the treatment of cSSSI.
The first isolate was susceptible to colistin but none of the other antimicrobial agents tested (cefepime, ceftriaxone, ceftazidime, aztreonam, amikacin, ciprofloxacin, trimethoprim/sulfamethoxazole, ertapenem, imipenem, and meropenem)whereas the second isolate was susceptible only to tigecycline.
In two identically designed multinational, double-blind, noninferiority phase III studies of almost 1,400 patients with a variety of cSSSI, patients were randomized to treatment with ceftaroline monotherapy (at the proposed dose for 5-14 days), or vancomycin (1 g IV every 12 hours) plus aztreonam (1 g IV every 12 hours) for 5-14 days.
Antimicrobial discs used were ampicillin (10), amoxycillin/clavulanic acid (10/20), piperacillin (100), piperacillin/tazobactem (100), ticarcillin (75), ticarcillin/clavulanic acid (75/10), cefixime (5), cefuroxime (30), cefpodoxime (10), cephotaxime (30), ceftazidime (30), aztreonam (30), netilmycin (30), amikacin (30), gentamycin (30), chlorophenicol (30), co-trimoxazol (30), tetracycline (30), imipenam (10) and meropenam (10).
The Food and Drug Administration refused to approve the biotech company's experimental cystic fibrosis drug, aztreonam lysine.
5) To be considered an ESBL, the organisms must be able to break down third and fourth generation cephalosporins (cefotaxime, ceftriaxone, cefepime, and ceftazidime) as well as aztreonam.