azoles


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Related to azoles: Allylamines

azoles

fungistatic agents (e.g. miconazole; clotrimazole) used daily for at least 4 weeks to treat tinea pedis (Table 1)
Table 1: Treatment of fungal infections of skin and nails
Infection siteAgent
Antimycotic agent (for the treatment of dermatophytosis)
SkinTopical allylamine (e.g. 1% terbinafine cream for 7 days)
Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days)
Topical 0.25% amorolfine
Topical 1% econazole
Topical griseofulvin spray (400 μg puff daily for 14 days)
Topical 1% sulconazole
Topical tea tree (manuka) oil
Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid)
Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid)
Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder
Systemic terbinafine (250 mg daily for 2 weeks)
Systemic itraconazole (100 mg daily for 15 days)
Systemic griseofulvin (500 mg daily )
NailTopical amorolfine 0.25% lacquer as an adjunct to systemic treatment
Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid)
Topical 28% tioconazole lacquer
Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil)
Other topicals: strong iodine 10% solution
Systemic terbinafine (250 mg daily for 12-16 weeks)
Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times)
Anticandidal agent (for the treatment of candidiasis)
SkinTopical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole)
Topical nystatin (100 000 units ± 1% tolnaftate)
Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
SkinTopical 2% ketoconazole
Topical 2.5% selenium sulphide
Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine)
Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole
References in periodicals archive ?
hematologic malignancy) during treatment with azole antifungal agents, including CRESEMBA.
Fungemia was detected in samples from 37 of 68 patients (54%) while they were being treated with antifungal agents, specifically with echinocandins (n = 21, 57%), ampB (n = 9, 24%), azoles (n = 6, 16%), or antifungal combinations (n = 1, 3%) (Table 2).
Moreover, the widespread use of antifungal drugs has led to the development of drug-resistant isolates, and resistance to azole antifungals continues to be a significant problem in the common fungal pathogen C.
So when I have a moist macerated space, I like an azole.
Azoles bind to cytochrome P-450 fungal enzyme, resulting in a decrease in synthesis of ergosterol and an increase in permeability of the membrane.
Overall 14 per cent of Candida species were resistant to at least one of the three azoles tested.
Essentially, the azoles are not used for life-threatening mycoses.
Researchers already knew existing anti-fungal drugs called azoles target P450s as a way to treat systemic and superficial infections caused by fungi such as thrush.
Azoles remain the basis of fungicide programmes targeted against this disease, although field results show that the average field performance of all fungicides in this group has fallen significantly since the mid-1990s.
More potent than other azoles but with more adverse effects, so generally reserved for serious infections.
This broad use of azoles is based on their inhibition of certain pathways of steroidogenesis by high-affinity binding to the enzymes sterol 14[alpha]-demethylase and aromatase.
As the number of patients treated with azoles and the duration of antifungal therapy have increased during the last decade, azole resistance has emerged as a major problem (2).