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azole antifungal |
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azole antifungal, any of a group of antifungals characterized by the presence of an azole ring structure, which includes the triazoles and the imidazoles (qq.v.). They are usually fungistatic but can be fungicidal at higher concentrations and act by interfering with the enzyme activity of cytochrome P-450, decreasing the production of ergosterol and so damaging the cell membrane by altering its permeability and functions. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although the list of inhibitors and inducers of the CYP enzymes is extensive, commonly used medications that inhibit the CYP enzymes include the macrolide antibiotics, cimetidine, antiretroviral agents, azole antifungal agents (ketoconazole, itraconazole, and fluconazole), cyclosporine, grapefruit juice, etc. fumigatus isolates exposed to azole antifungal agents (39,40). However, not all human fungal pathogens are susceptible to azole antifungal medications and resistance is an increasing problem. |
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