azole antifungal

azole antifungal

any of a group of antifungals characterized by the presence of an azole ring structure, which includes the triazoles and the imidazoles (qq.v.). They are usually fungistatic but can be fungicidal at higher concentrations and act by interfering with the enzyme activity of cytochrome P-450, decreasing the production of ergosterol and so damaging the cell membrane by altering its permeability and functions.
References in periodicals archive ?
Indications and Usage CRESEMBA is an azole antifungal indicated for patients 18 years of age and older for the treatment ofinvasive aspergillosis and invasive mucormycosis.
Purpose: The present study investigated the antifungal effect of 2',4,-dihydroxy-5'-(1'",1'"-dimethylallyl)- 8-prenylpinocembrin (8PP, formerly 6PP), a natural prenylflavonoid, on Candida albicans biofilms, and compared this with an azole antifungal (fluconazole) by studying the cellular stress and antioxidant response.
Cresemba belongs to a class of drugs called azole antifungal agents, which target the cell wall of a fungus.
Voriconazole is a second-generation azole antifungal agent.
Rhabdomyolysis has been reported with these drugs and the risk of this serious condition is increased with the use of macrolide antibiotics, such as Biaxin (clarithromycin) and azole antifungal agents, such as Diflucan (fluconazole).
ONMEL[TM] (itraconazole), an azole antifungal, was approved by the FDA in April 2010 and is indicated for the treatment of onychomycosis of the toenail caused by Trichophyton rubrum or T.
It also increases concentrations of alcohol, azole antifungal drugs, and flu-voxamine, and decreases rifampin levels.
1) Disseminated and visceral infections are usually treated with Amphotericin B, whereas the azole antifungal agents, especially itraconazole, are used for more localized infections.
to co-develop and co-promote isavuconazole, an azole antifungal for the treatment of invasive fungal infections, including Aspergillosis, currently in Phase 3 trials; and with Optimer Pharmaceuticals Inc.
Other medications, including azole antifungal agents and macrolide antibiotics, might inhibit the cytochrome P450 system and require decreased doses of methadone.
Most nonalbicans Candida species have higher minimum inhibitory concentrations (MICs) to the azole antifungal agents, and infections they cause are often difficult to treat (3,4).
Although the list of inhibitors and inducers of the CYP enzymes is extensive, commonly used medications that inhibit the CYP enzymes include the macrolide antibiotics, cimetidine, antiretroviral agents, azole antifungal agents (ketoconazole, itraconazole, and fluconazole), cyclosporine, grapefruit juice, etc.