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azole antifungal

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azole antifungal,
any of a group of antifungals characterized by the presence of an azole ring structure, which includes the triazoles and the imidazoles (qq.v.). They are usually fungistatic but can be fungicidal at higher concentrations and act by interfering with the enzyme activity of cytochrome P-450, decreasing the production of ergosterol and so damaging the cell membrane by altering its permeability and functions.


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Other medications, including azole antifungal agents and macrolide antibiotics, might inhibit the cytochrome P450 system and require decreased doses of methadone.
Although the list of inhibitors and inducers of the CYP enzymes is extensive, commonly used medications that inhibit the CYP enzymes include the macrolide antibiotics, cimetidine, antiretroviral agents, azole antifungal agents (ketoconazole, itraconazole, and fluconazole), cyclosporine, grapefruit juice, etc.
fumigatus isolates exposed to azole antifungal agents (39,40).
 
 
 
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