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azelaic acid |
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azelaic acid /az·e·la·ic ac·id/ (az″ĕ-la´ik) a topical antibacterial used in the treatment of acne vulgaris. azelaic acid [az′ĕ-la′ik] a dicarboxylic acid occurring in whole grains and animal products. It has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis; normalizes keratinization; and has a cytotoxic effect on malignant or hyperactive melanocytes. It is applied topically in the treatment of acne vulgaris. azelaic acid (az´ n brand name: Azelex; drug class: a naturally occurring straight-chain dicarboxylic acid; action: has antimicrobial activity against P. acnes and S. epidermidis; use: topical therapy of mild-tomoderate inflammatory acne vulgaris. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Antibiotics and azelaic acid help stop or slow the growth of P. Table 4-principal compounds used in manufacture of esters Organic acids Monobasic acids Dibasic acids Tribasic acids Oleic Phthalic anhydride Trimellitic anhydride Stearic Adipic acid Citric acid Benzoic Sebacic acid Pelargonic Azelaic acid Glutaric acid Organic alcohols Monohydric Dihydric Trihydric 2-Ethylhexanol Propylene glycol Glycerol Isodecanol 1,3 butandiol Trimethylolpropane 6-10 linear alcohols 1,4 butandiol Benzyl alcohol Isononyl alcohol [80] Maple PAC, Hamilton-Miller JMT, Brumfitt W, Comparison of the in-vitro activities of the topical antimicrobials azelaic acid, nitrofurazone, silver sulfadiazine and mupirocin against methicillin-resistant Staphylococcus aureus. |
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