azelaic acid


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azelaic acid

 [az″ĕ-la´ik]
a dicarboxylic acid occurring in whole grains and animal products; it has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis, normalizes keratinization, and has a cytotoxic effect on malignant or hyperactive melanocytes; applied topically in the treatment of acne vulgaris.

azelaic acid

/az·e·la·ic ac·id/ (az″ĕ-la´ik) a topical antibacterial used in the treatment of acne vulgaris.

azelaic acid

[az′ĕ-la′ik]
a dicarboxylic acid occurring in whole grains and animal products. It has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis; normalizes keratinization; and has a cytotoxic effect on malignant or hyperactive melanocytes. It is applied topically in the treatment of acne vulgaris.

azelaic acid

A substance first identified in rancid oleic acid which interferes with anerobic glycolysis and mitochondrial activity. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, possibly by inhibiting microbial protein synthesis.

Dermatology
AZELEX Cream is indicated for the topical treatment of mild to moderate inflammatory acne vulgaris; another formulation, Finacea, is a topical gel used to manage inflammatory papules and pustules of mild to moderate rosacea.

Fringe oncology
Some anecdotal data suggest possible efficacy of alelaic acid in managing lentigo maligna, a form of melanoma.

azelaic acid

An antibacterial drug used externally in the form of a skin cream. A brand name is Skinoren.

azelaic acid (az´əla´ik),

n brand name: Azelex;
drug class: a naturally occurring straight-chain dicarboxylic acid;
action: has antimicrobial activity against
P. acnes and
S. epidermidis; use: topical therapy of mild-tomoderate inflammatory acne vulgaris.
References in periodicals archive ?
The panelists largely agreed that azelaic acid cream 20% or gel 15% can be useful to treat acne in pregnant women and patients with acne and postinflammatory hyperpigmention, although some said it can cause irritation and aggravate already inflamed skin.
In July 27, 2012, Glenmark Pharmaceuticals submitted an Abbreviated New Drug Application (ANDA) with the Food and Drug Administration for a generic Azelaic Acid Gel, 15% formulation.
Azelaic Acid (20%): It is a naturally occurring dicarboxylic acid which acts by anti- tyrosinase activity.
The most commonly used antiseptics include 3benzoyl peroxide (the most widely used one), azelaic acid and sodium sulfacetamide.
Summary: In order to synthesize more function amides, N, N'-bis(benzoyl) azelaic acid dihydrazide(NA(A)) was synthesized from benzoyl hydrazine and azelaoyl chloride which was deprived from azelaic acid via acylation.
Talk to your physician about a prescription azelaic acid product (such as Azelex).
Topical bleaching agents such as hydroquinone, kojic acid and azelaic acid can reduce signs of aging.
Treatments available will include creams and gels - which will probably be effective for the majority of simple cases - and if these don't work, other options include specific antibiotic medicines, the use of azelaic acid on the affected area or laser treatment on blood vessels.
Examples are: azelaic acid, benzoyl peroxide, clindamycin, erythromycin and sodium sulfacetamide.
Azelaic acid (AZA) LR (99%), maleic anhydride LR (98%), triethyl amine LR (99%), trimethylol propane (TMP, 98%), neopentyl glycol (NPG, 99%), and catalyst AIBN were procured from s.