azelaic acid


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azelaic acid

 [az″ĕ-la´ik]
a dicarboxylic acid occurring in whole grains and animal products; it has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis, normalizes keratinization, and has a cytotoxic effect on malignant or hyperactive melanocytes; applied topically in the treatment of acne vulgaris.

azelaic acid

/az·e·la·ic ac·id/ (az″ĕ-la´ik) a topical antibacterial used in the treatment of acne vulgaris.

azelaic acid

[az′ĕ-la′ik]
a dicarboxylic acid occurring in whole grains and animal products. It has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis; normalizes keratinization; and has a cytotoxic effect on malignant or hyperactive melanocytes. It is applied topically in the treatment of acne vulgaris.

azelaic acid

A substance first identified in rancid oleic acid which interferes with anerobic glycolysis and mitochondrial activity. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, possibly by inhibiting microbial protein synthesis.

Dermatology
AZELEX Cream is indicated for the topical treatment of mild to moderate inflammatory acne vulgaris; another formulation, Finacea, is a topical gel used to manage inflammatory papules and pustules of mild to moderate rosacea.

Fringe oncology
Some anecdotal data suggest possible efficacy of alelaic acid in managing lentigo maligna, a form of melanoma.

azelaic acid

An antibacterial drug used externally in the form of a skin cream. A brand name is Skinoren.

azelaic acid (az´əla´ik),

n brand name: Azelex;
drug class: a naturally occurring straight-chain dicarboxylic acid;
action: has antimicrobial activity against
P. acnes and
S. epidermidis; use: topical therapy of mild-tomoderate inflammatory acne vulgaris.
References in periodicals archive ?
Comment: Azelaic acid is a 9-carbon straight-chain dicarboxylic acid that occurs naturally in some foods.
Eye and Mucous Membranes Irritation: Azelaic acid has been reported to cause irritation of the eyes.
Since, no reports are available on the interaction of azelaic acid with Chitosan and type -I collagen, in the present study, we attempted to prepare biopolymers using azelaic acid as cross-linker for the natural polymers chitosan and type-I collagen.
1] (Mn = 1050) (12) (ASTM D 1957-286) was synthesized using azelaic acid, maleic anhydride, neopentyl glycol, and trimethylol propane (branching monomer) according to the formulations given in Table 2.
Worret W-I, Fluhr JW: Acne therapy with topical benzoylperoxide, antibiotics and azelaic acid.
SAN FRANCISCO -- For treatment of acne or rosacea in pregnancy, think first, and last, of azelaic acid gel 15% twice daily, Dr.
The team, which includes Tim Tschaplinski of the Department of Energy's ORNL, has determined that azelaic acid has a role in priming the immunity response in Arabidopsis, a small flowering plant related to cabbage and mustard.
CREAMS, GELS AND LOTIONS: These are applied directly on to the skin and contain active anti-acne ingredients such as benzoyl peroxide, nicotinamide, antibiotics, azelaic acid and vitamin A (retinol).
Treatment applied to the skin such as azelaic acid or benzoyl peroxide will usually be sufficient for mild to moderate acne.
Another niche agent is Azelex, a 20% azelaic acid cream that improves hyperpigmentation, particularly in swarthy or African American patients or those with hypersensitization or hyperpigmentation from benzoyl peroxide or retinoids.
The cream contains Green Coffee Extract, Seaweed, Kola, Centella Asiatica, Azelaic Acid, Niacin, Elastin and Kigelia Africana.
For example, oleic acid is a common unsaturated fatty acid that can be oxidized with ozone to produce azelaic acid and pelargonic acid.