axonopathy

axonopathy

 [ak″sŏ-nop´ah-the]
a disorder disrupting the normal functioning of the axons.

ax·o·nop·a·thy

(aks'on-op'a-thē),
A disorder affecting primarily the axons of peripheral nerve fibers (although secondary demyelination occurs), in contrast to one affecting only myelin (myelinopathy).

axonopathy

/axo·nop·a·thy/ (ak″sah-nop´ah-the) a disorder disrupting the normal functioning of the axons; in distal a. the disease progresses from the center toward the periphery and in proximal a. the disease progresses from the periphery toward the center.

axonopathy

a disease of axons.

Boxer progressive axonopathy
an inherited, degenerative disorder of the peripheral and central nervous system in Boxer dogs. By 6 months of age, dogs homozygous for the trait show ataxia and weakness in the hindlimbs and an absence of the patellar reflex.
congenital axonopathy
Holstein-Friesian calves are recumbent from birth; the necropsy lesion is degeneration in spinal cord and midbrain nerve tracts; considered to be inherited as an autosomal recessive trait.
inherited ovine degenerative axonopathy
inherited in several forms in some sheep breeds (Suffolk, Merino, Coopworth); may be congenital or develop at up to 6 months old; signs include ataxia, recumbency, invariable death. Probably the same disease as that called Murrurrundi disease.
peripheral and central distal axonopathy of Birman cats
see distal polyneuropathy of Birman cats.
segmental axonopathy
axonopathy affecting a segment of the axons.
References in periodicals archive ?
1-3) The electrophysiological examination including both nerve conduction and electromyography studies should identify peripheral nerve dysfunction if present, along with the specific location in the nerve pathway, involvement of sensory and/or motor axons, and the presence of myelinopathy and/or axonopathy neuropathic process.
Hereditary spastic paraplegia (HSP) includes a large and diverse group of genetic disorders whose main feature is progressive spasticity and weakness in the lower limbs, as a result of continuous distal axonopathy caused by defects in the mechanisms that transport proteins and substances along the axons [90, 91].
The findings on nerve conduction studies were in keeping with a sensorimotor axonopathy.
The most common form of DN is a length-dependant symmetrical distal axonopathy that may be relentlessly progressive or may remain stable for years.
Imaging studies show the virus attacking at the anterior horns of the spinal cord; nerve conduction studies show a motor axonopathy, but without much demyelination.
9] Bansal et al (2006) have suggested that the slowing of NCV indicates the ongoing damage to the myelin sheaths and they are also of the opinion that the amplitude decreases with the rising HbA1c levels, thus suggesting the onset of axonopathy.
An infant with Marfanoid phenotype and congenital contractures associated with ocular and cardiovascular anomalies, cerebral white matter hypoplasia and spinal axonopathy.
Disease Pathology Inheritance Genes/chromosomal name (a) mode loci associated with disease, n CMT1 Abnormal myelin AD (b) 9 CMT2 Axonopathy AD 19 CMT4 Either myelinopathy AR 10 or axonopathy CMTX Axonopathy with XLD 2 secondary myelin changes Disease Proportion name (a) of all CMT, % CMT1 40-50 CMT2 10-15 CMT4 Rare CMTX 10-15 (a) Intermediate dominant (dominant inheritance with NCV between demylinating and axonopathic) and other rare forms are not included.
2002) Tau and axonopathy in neurodegenerative disorders.
2] Organophosphate induced delayed polyneuropathy (OPIDP), a sensory-motor distal axonopathy, usually occurs 1-4 weeks after single or short-term exposures and it may be progressive and severe.
ACR Neurotoxicity: Evolving Neurobiological Concepts of the Distal Axonopathy
With hind limbs hyperflexion and a abnormal gait because of distal axonopathy with skeletal muscle denervation and atrophy.