axonal degeneration

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ax·o·nal de·gen·er·a·tion

a type of peripheral nerve fiber response to insult, wherein axon death and subsequent breakdown occur, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibers; often referred to as wallerian degeneration.
Synonym(s): axon degeneration


pertaining to or arising from an axon.

axonal degeneration
an axon dies and cannot be replaced if its cell body is destroyed. A damaged axon in the central nervous system similarly cannot undergo regeneration, but a peripheral nerve with an intact nerve cell can regenerate. See also wallerian degeneration.
axonal dystrophy
specific diseases characterized by nutritional abnormalities of axons include in sheep, Suffolk, Coopworth, Merino axonal dystrophies, in dogs, Rottweiler, Chiahuahua dystrophies, in horses Haflinger, Morgan, in cats a dystrophy in lilac coat color domestic shorthaired.
giant axonal neuropathy
see giant axonal neuropathy.
axonal migration
the movement of axoplasm from the proximal segment of a severed nerve fiber to the distal portion, following Schwann cell extensions, in the process of peripheral nerve regeneration.
axonal reaction
central chromatolysis of the axon characterized by eccentric relocation of the nucleus, greater prominence of the nucleolus and a basophilic cap of RNA on its cytoplasmic aspect, dispersal of the Nissl substance to the periphery of the cell, and an increase in the number of neurofilaments.
References in periodicals archive ?
In this study we aimed to compare vasculitic neuropathy and axonal neuropathy without an identifiable cause because both groups show axonal degeneration in their pathology and a demyelinating hereditary neuropathy HNPP as a control group.
This observation is not sufficient to speculate a prominent role of the RAGE pathway in axonal degeneration but supports the fact that the RAGE pathway is one of the activated pathway in macrophages without need of inflammatory milieu.
On the other hand, in addition to the localized axonal degeneration, atrophy might develop in the nerve fibers in the distal of the compression.
Facial neuropathy due to axonal degeneration and microvasculitis following gamma knife surgery for vestibular schwannoma: A histological analysis.
The slow recovery cannot be explained by an axonal degeneration process, since EMG never showed spontaneous activity.
LRRK2 Mediated Pathogenic Pathways in Dopaminergic Axonal Degeneration and Synaptic Transmission
The compound, called nicotinamide riboside (NR) - a natural NAD+ precursor found in foods like milk - as well as other NR derivatives have already been proven to protect against cell death and axonal degeneration in cultured cells and in models of spinal cord injury.
A nerve conduction study revealed polyneuropathy with motor-predominant axonal degeneration.
Exposure to nitrous oxide "has been shown to cause axonal degeneration or block axonal conduction, especially in axons that are physiologically active or demyelinated.
During the 19th century, Waller elucidated the process of axonal degeneration following nerve transection.
33] Axonal degeneration is retrograde, the axon shrinking back toward the neuronal cell body.
In another important pair of studies, the CFC discovered that the cell death that causes vision loss in glaucoma has two distinct phases, and that axonal degeneration precedes neuronal loss.