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axonal |
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axonal pertaining to or arising from an axon. axonal degeneration an axon dies and cannot be replaced if its cell body is destroyed. A damaged axon in the central nervous system similarly cannot undergo regeneration, but a peripheral nerve with an intact nerve cell can regenerate. See also wallerian degeneration. axonal dystrophy specific diseases characterized by nutritional abnormalities of axons include in sheep, Suffolk, Coopworth, Merino axonal dystrophies, in dogs, Rottweiler, Chiahuahua dystrophies, in horses Haflinger, Morgan, in cats a dystrophy in lilac coat color domestic shorthaired. giant axonal neuropathy see giant axonal neuropathy. axonal migration the movement of axoplasm from the proximal segment of a severed nerve fiber to the distal portion, following Schwann cell extensions, in the process of peripheral nerve regeneration. axonal reaction central chromatolysis of the axon characterized by eccentric relocation of the nucleus, greater prominence of the nucleolus and a basophilic cap of RNA on its cytoplasmic aspect, dispersal of the Nissl substance to the periphery of the cell, and an increase in the number of neurofilaments. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The authors also observed spherical axonal swellings and expanded motor end plates and postulated that spindle modifications may be the result of dennervation. Histopathologic examination of sections from the cortex, hippocampus, thalamus, hypothalamus, midbrain, pons, medulla, and cerebellum showed polioencephalitis affecting predominantly the diencephalon and brainstem and involving varying degrees of neuronopathy, neuronal loss, astrocytosis, parenchymal and perivascular lymphocytic infiltration with CD45 immunopositivity, sparse macrophage activation, and axonal spheroid formation. Uremia, ototoxins, axonal uremic neuropathy, anemia, and toxic degradation products from cellulose acetate dialyzer membranes are all possible etiologic factors. |
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