axonal degeneration

(redirected from axon degeneration)

ax·o·nal de·gen·er·a·tion

a type of peripheral nerve fiber response to insult, wherein axon death and subsequent breakdown occur, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibers; often referred to as wallerian degeneration.
Synonym(s): axon degeneration


pertaining to or arising from an axon.

axonal degeneration
an axon dies and cannot be replaced if its cell body is destroyed. A damaged axon in the central nervous system similarly cannot undergo regeneration, but a peripheral nerve with an intact nerve cell can regenerate. See also wallerian degeneration.
axonal dystrophy
specific diseases characterized by nutritional abnormalities of axons include in sheep, Suffolk, Coopworth, Merino axonal dystrophies, in dogs, Rottweiler, Chiahuahua dystrophies, in horses Haflinger, Morgan, in cats a dystrophy in lilac coat color domestic shorthaired.
giant axonal neuropathy
see giant axonal neuropathy.
axonal migration
the movement of axoplasm from the proximal segment of a severed nerve fiber to the distal portion, following Schwann cell extensions, in the process of peripheral nerve regeneration.
axonal reaction
central chromatolysis of the axon characterized by eccentric relocation of the nucleus, greater prominence of the nucleolus and a basophilic cap of RNA on its cytoplasmic aspect, dispersal of the Nissl substance to the periphery of the cell, and an increase in the number of neurofilaments.
References in periodicals archive ?
However, its physiological roles, and how it could influence axon degeneration, are poorly understood.
My work will examine the interplay between ER and mitochondria in axons for the first time, and mechanisms of dysfunction that are relevant for human axon degeneration.
This model has the advantage of avoiding overt damage to ocular structures, which will cause inflammatory responses, while it can effectively induce RGCs and axon degeneration that simulates the progression of glaucoma.
In this study, the state of RGCs and axon degeneration was assessed by retrograde labeling with FG and [sz]-III-tubulin immunohistochemistry.
He supported the hypothesis that inflammation is necessary for new lesion formation and conditions causing axon degeneration and therefore early, more efficacious treatment of inflammation with more potent immunomodulatory agents such as alemtuzumab, may inhibit the establishment of immunological chronicity and may protect the CNS from degeneration.
The articles discuss research of the UPS in connection with the development and diseases of the nervous system and include such topics as the UPS in axon degeneration, the UPS in pain transmission and neuropathic pain, ubiquitin- dependent proteolysis in Parkinson's disease, ubiquitin domain proteins, and the functional role of proteasome antibodies in neurological disorders.
This finding may hold more promise for injuries or early demyelination, in which axon degeneration has yet occurred.
Examining the brains of young dogs, Siegel and his coworkers found three regions in which narcoleptic dogs showed much more axon degeneration than do normal dogs.
Since human narcoleptics live to normal ages, says Siegel, evidence of the axon degeneration could largely have disappeared by the time a patient dies, explaining why autopsies of narcoleptics have not revealed obvious brain abnormalities.
Neuronal remodeling of the Drosophila mushroom body offers a unique opportunity to study the mechanisms of various types of axon degeneration and growth.
Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape.
This new finding, along with in vitro work from other groups, indicates that promoting axonal protein synthesis is a key mechanism by which trophic factors act to prevent axon degeneration.