autosomal-dominant inheritance

autosomal-dominant inheritance

a pattern of inheritance in which the transmission of a dominant allele on an autosome causes a trait to be expressed. Males and females are usually affected with equal frequency. If both parents are heterozygous (Aa), each of their children has a 50% chance of being heterozygous, a 25% chance of being homozygous for the dominant allele (AA), and a 25% chance of being homozygous for the recessive allele (aa); children with either of the first two genotypes will express the trait of the dominant allele. If one parent is homozygous for the dominant allele, all of the children will express the trait. Achondroplasia, osteogenesis imperfecta, polydactyly, Marfan's syndrome, and some neuromuscular disorders are transmitted through autosomal-dominant inheritance. Compare autosomal-recessive inheritance. See also dominance.

autosomal-dominant inheritance

genetic inheritance pattern where an abnormal gene (inherited from one parent) is dominant over the normal gene (inherited from the other parent); the individual shows the characteristics associated with the abnormal gene
References in periodicals archive ?
Primary extracranial meningiomas of the head and neck have also shown to have a relationship with neurofibromatosis, particularly type 2 NF characterized by bilateral acoustic schwannomas and lack of skin findings and having a defect on chromosome 22q with an autosomal-dominant inheritance pattern [3].
This family exhibits autosomal-dominant inheritance of this abnormality.
8, 9) The mode of inheritance of the disease is unclear, but both autosomal-recessive and autosomal-dominant inheritance have been suggested.
Neurofibromatosis type 1 should be distinguished from neurofibromatosis type 2, which is also a genetic disorder with an autosomal-dominant inheritance pattern.
It has autosomal-dominant inheritance with complete penetrance and variable expressivity.
The theory of genetic transmission by an autosomal-dominant inheritance mechanism is supported by two reports of familial cases, (2,3) but this is not the most common scenario.
13) Although some evidence of autosomal-dominant inheritance has been noted, most patients with velocardiofacial syndrome do not report a family history suggestive of this syndrome.

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