autophagic vacuole

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Related to autophagic vacuole: heterophagy


A variety of secondary lysosome that contains the remnants of mitochondria, ribosomes, or other organelles.
Synonym(s): autophagic vacuole


A membrane-bound intracellular vacuole that contains fragments of partially digested cell components; indigestible debris persists as lipofuscin.

autophagic vacuole

A vacuole that contains recognizable fragments of the ribosomes or mitochondria.
See also: vacuole
References in periodicals archive ?
20) Moreover, Rab9 silencing by a targeted siRNA reduced the number of autophagic vacuoles, but induced the accumulation of isolation membranes.
23) Ultrastructural analysis also demonstrated that autophagic vacuoles in reticulocytes engulfed and digested mitochondria in both wild-type and Atg5-deficient embryos (Fig.
The generation of autophagic vacuoles in alternative autophagy is mediated by the fusion of isolation membranes with vesicles derived from the trans-Golgi as well as late endosomes, in a Rab9-dependent manner.
In addition, PSO-induced accumulation of autophagic vacuoles in MDC staining was remarkably reduced by NAC or DPI as evidenced by the decreased green fluorescence (Fig.
MDC staining is a simple method to monitor the accumulation of autophagic vacuoles (Vazquez and Colombo 2009).
Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA.
AO was protonated by entering the acidic lysosomes and emit orange light; MDC was accumulated in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids (Chang et al.
Colombo, "Chapter 6 assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using Monodansylcadaverine (MDC) and DQ-BSA," Methods in Enzymology, vol.
Rimmed or autophagic vacuoles were identified in all cases and were best highlighted on the Gomori trichrome stain (Figure 1).
In most cases, these inclusions were identified within muscle fibers that contained autophagic vacuoles.
Sterol biosynthesis inhibitors also induced ultrastructural changes in other organelles, such as the nucleus and plasma membrane, and promoted the formation of autophagic vacuoles.
Ultrastructural analysis also showed that compound (3) induced intense atypical cytoplasmic vacuolization and the appearance of autophagic vacuoles in L.